DL-2-氨基-2-苯基丙酸合成路线 （共 23 条）
反应条件
hydrogen bromide; acetic acid; phenol T=75°C;
参考文献
Hartmann, Caroline E.; Baumann, Thomas; Baechle, Michael; Braese, Stefan
Tetrahedron Asymmetry, 2010 , vol. 21, # 11-12 p. 1341 - 1349
反应条件
1: With pyridine T=40°C; 15 h; 2: With trifluoroacetic anhydride T=20°C; 48 h; Further stages;
参考文献
Hartmann, Caroline E.; Baumann, Thomas; Baechle, Michael; Braese, Stefan
Tetrahedron Asymmetry, 2010 , vol. 21, # 11-12 p. 1341 - 1349
反应条件
hydrogenchloride 24 h; Heating;
参考文献
Shuman, Robert T.; Rothenberger, Robert B.; Campbell, Charles S.; Smith, Gerald F.; Gifford-Moore, Donetta S.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4446 - 4453
反应条件
1: aq. H2O2; NaH2PO4; NaClO2 / acetonitrile / 12 h / cooling 2: 0.460 g / toluene; methanol; diethyl ether / 0.08 h / 0 °C 3: 88 percent / aq. HBr; phenol; AcOH / 75 °C View Scheme
参考文献
Organic Letters, , vol. 8, # 17 p. 3797 - 3800
反应条件
1: 0.460 g / toluene; methanol; diethyl ether / 0.08 h / 0 °C 2: 88 percent / aq. HBr; phenol; AcOH / 75 °C View Scheme
参考文献
Organic Letters, , vol. 8, # 17 p. 3797 - 3800
反应条件
1: 90 percent / L-proline / acetonitrile / 0.5 h / 60 °C / microwave irradiation 2: aq. H2O2; NaH2PO4; NaClO2 / acetonitrile / 12 h / cooling 3: 0.460 g / toluene; methanol; diethyl ether / 0.08 h / 0 °C 4: 88 percent / aq. HBr; phenol; AcOH / 75 °C View Scheme
参考文献
Organic Letters, , vol. 8, # 17 p. 3797 - 3800
反应条件
ammonium hydroxide; ethanol; ammonium chloride T=60°C; man kocht das Reaktionsprodukt mit verd. Salzsaeure; dl-amino-hydratropic acid;
参考文献
Journal of Biological Chemistry, , vol. 76, p. 313
Organic Syntheses, , vol. 24, p. 9
反应条件
hydrogenchloride T=20°C; Behandeln dann mit verd. Salzsaeure und Alkohol;
参考文献
Chemische Berichte, , vol. 14, p. 1980
反应条件
1: 92 percent / potassium hydrogenphosphate; sodium chlorite; H2O2 / H2O; acetonitrile / 1 h / 20 °C 2: 100 percent / NaOMe / methanol; dioxane / 18 h / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 23 p. 5315 - 5338
