3-甲基-3-戊烯-2-酮合成路线 （共 23 条）
反应条件
1: palladium on activated charcoal; hydrogen / 3.5 h / 85 °C / 7500.75 Torr / |Large scale 2: sodium methylate / methanol; toluene / 5 h / 0 - 20 °C / |Large scale 3: sodium hydroxide / water / 80 - 90 °C / pH 2 4: 80 - 90 °C View Scheme
参考文献
International Flavors and Fragrances Inc.; Adell Gavalda, Juan; P.S. Narula, Anubhav; Collado Perez, Ana Maria
Patent: EP2708536 A1, 2014 ;
反应条件
1: 64 percent / sodium ethoxide / ethanol / 72 h / 0 °C 2: 74 percent / conc. H2SO4 / H2O / reflux, overnight 3: 66 percent / acetyl chloride / 4 h / Heating 4: 11 percent / 1.) N-bromosuccinimide, 2.) triethylamine / 1.) benzoyl peroxide View Scheme
参考文献
Pavlik, James W.; Patten, Arthur D.; Bolin, David R.; Bradford, Kenneth C.; Clennan, Edward L.
Journal of Organic Chemistry, 1984 , vol. 49, # 23 p. 4523 - 4531
参考文献
Lachance,P. et al.
Canadian Journal of Chemistry, 1979 , vol. 57, p. 367 - 376
反应条件
1: palladium on activated charcoal; hydrogen / 3.5 h / 85 °C / 7500.75 Torr / |Large scale
2: sodium methylate / methanol; toluene / 5 h / 0 - 20 °C / |Large scale
View Scheme
参考文献
International Flavors and Fragrances Inc.; Adell Gavalda, Juan; P.S. Narula, Anubhav; Collado Perez, Ana Maria
Patent: EP2708536 A1, 2014 ;
反应条件
1: palladium on activated charcoal; hydrogen / 3.5 h / 85 °C / 7500.75 Torr / |Large scale
2: sodium methylate / methanol; toluene / 5 h / 0 - 20 °C / |Large scale
3: sodium hydroxide / water / 80 - 90 °C / pH 2
4: 80 - 90 °C
5: sodium hydroxide; water / 80 °C
View Scheme
参考文献
International Flavors and Fragrances Inc.; Adell Gavalda, Juan; P.S. Narula, Anubhav; Collado Perez, Ana Maria
Patent: EP2708536 A1, 2014 ;
反应条件
copper(l) chloride in diethyl ether
T=-30°C;
参考文献
Lachance, Pierre; Eastham, Arthur M.
Canadian Journal of Chemistry, 1981 , vol. 59, p. 2621 - 2628
反应条件
1: Ru/Al; hydrogen / 7 h / 150 °C / 22502.3 Torr / |Large scale
2: methanesulfonic acid / 130 °C / |Large scale
View Scheme
参考文献
International Flavors and Fragrances Inc.; Adell Gavalda, Juan; P.S. Narula, Anubhav; Collado Perez, Ana Maria
Patent: EP2708536 A1, 2014 ;
反应条件
1: 63 percent / CuCl / diethyl ether / -30 °C
View Scheme
参考文献
Lachance, Pierre; Eastham, Arthur M.
Canadian Journal of Chemistry, 1981 , vol. 59, p. 2621 - 2628
反应条件
in tetrahydrofuran; diethyl ether
T=-23°C; 0.25 h;
参考文献
Fleming, Ian; Lewis, Jeremy J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 24 p. 3257 - 3266
反应条件
trichlorophosphate
1.) 30 min, room temperature, 2.) 4-4.5 h, boiling water-bath;
参考文献
Sreenivasulu, M.; Rao, G. S. Krishna
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1989 , vol. 28, # 1-11 p. 494 - 495
