4,5-二氢环戊并[b]噻吩-6-酮合成路线 （共 20 条）
参考文献
Journal de Chimie Physique et de Physico-Chimie Biologique, , vol. 86, # 1 p. 93 - 98
反应条件
1: 1.) NaOH; 2.) HCl 2: 200 °C 3: 100 percent / SOCl2 4: 60 percent / AlCl3 5: Zn/CH3COOH View Scheme
参考文献
Journal de Chimie Physique et de Physico-Chimie Biologique, , vol. 86, # 1 p. 93 - 98
反应条件
1: 50 percent / NaH 2: 1.) NaOH; 2.) HCl 3: 200 °C 4: 100 percent / SOCl2 5: 60 percent / AlCl3 6: Zn/CH3COOH View Scheme
参考文献
Journal de Chimie Physique et de Physico-Chimie Biologique, , vol. 86, # 1 p. 93 - 98
反应条件
1: 100 percent / SOCl2 2: 60 percent / AlCl3 3: Zn/CH3COOH View Scheme
参考文献
Journal de Chimie Physique et de Physico-Chimie Biologique, , vol. 86, # 1 p. 93 - 98
反应条件
1: 60 percent / AlCl3 2: Zn/CH3COOH View Scheme
参考文献
Journal de Chimie Physique et de Physico-Chimie Biologique, , vol. 86, # 1 p. 93 - 98
反应条件
1: 200 °C 2: 100 percent / SOCl2 3: 60 percent / AlCl3 4: Zn/CH3COOH View Scheme
参考文献
Journal de Chimie Physique et de Physico-Chimie Biologique, , vol. 86, # 1 p. 93 - 98
反应条件
1.1: hydroxylamine hydrochloride; sodium acetate / methanol / 20 °C 1.2: Polyphosphoric acid Polyphosphoric acid Polyphosphoric acid polyphosphoric acid / 2 h / 130 °C 2.1: bromine; acetic acid / water / 1.5 h / 0 °C View Scheme
参考文献
Augeri, David John; Bagdanoff, Jeffrey Thomas; Baugh, Simon David Peter; Carlsen, Marianne; Carson, Kenneth Gordon; Gilleran, John Anthony; He, Wei; Oravecz, Tamas; Salojin, Konstantin; Sung, Leonard
Patent: US2012/225857 A1, 2012 ;
反应条件
1: With hydroxylamine hydrochloride; sodium acetate in methanol T=20°C; 2: T=130°C; 0.5 h; Product distribution / selectivity;
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/146758 A2, 2007 ;
Location in patent: Page/Page column 32-33 ;
WO 2007/146758 A2
反应条件
1: 71 percent / NBS, 1,1'-azobis(cyclohexanecarbonitrile) / CCl4 / 5 h / Heating 2: 98 percent / acetic acid / 24 h / Heating View Scheme
参考文献
Hauze, Diane B.; Joullie, Madeleine M.; Ramotowski, Robert; Cantu, Antonio
Tetrahedron, 1997 , vol. 53, # 12 p. 4239 - 4246
反应条件
1.1: 81 percent / LDA / tetrahydrofuran / 12 h / 20 °C
2.1: KOH; iodobenzene diacetate / methanol / 24 h / 20 °C
2.2: 65 percent / HCl / ethanol / 2.5 h / 20 °C
View Scheme
参考文献
Bonini, Bianca Flavia; Capito, Elena; Comes-Franchini, Mauro; Ricci, Alfredo; Bottoni, Andrea; Bernardi, Fernando; Miscione, Gian Pietro; Giordano, Laurent; Cowley, Andrew R.
European Journal of Organic Chemistry, 2004 , # 21 p. 4442 - 4451
