1-乙氧羰基氮杂环庚-4-酮合成路线 （共 7 条）
反应条件
1.1: nBuLi / tetrahydrofuran / 2 h / -78 °C 1.2: 64.3 percent / tetrahydrofuran / -78 - 20 °C 2.1: 73.8 percent / aq. KOH; hydrazine / ethanol / Heating View Scheme
参考文献
Lyles-Eggleston; Altundas; Xia; Sikazwe; Fan; Yang; Li; Zhang; Zhu; Schmidt; Vanase-Frawley; Shrihkande; Villalobos; Borne; Ablordeppey
Journal of Medicinal Chemistry, 2004 , vol. 47, # 3 p. 497 - 508
反应条件
potassium hydroxide in ethanol
T=20°C; 24 h;
参考文献
Lyles-Eggleston; Altundas; Xia; Sikazwe; Fan; Yang; Li; Zhang; Zhu; Schmidt; Vanase-Frawley; Shrihkande; Villalobos; Borne; Ablordeppey
Journal of Medicinal Chemistry, 2004 , vol. 47, # 3 p. 497 - 508
反应条件
boron trifluoride diethyl etherate in diethyl ether
T=-30 - -25°C; 1.33333 h; Cooling with iso-propanol-dry ice;
参考文献
SCHERING CORPORATION
Patent: WO2008/130581 A1, 2008 ;
Location in patent: Page/Page column 190-191 ;
WO 2008/130581 A1
反应条件
1: 88.8 percent / BF3*Et2O / diethyl ether / -30 - 20 °C
2: 84 percent / aq. KOH / ethanol / 24 h / 20 °C
View Scheme
参考文献
Lyles-Eggleston; Altundas; Xia; Sikazwe; Fan; Yang; Li; Zhang; Zhu; Schmidt; Vanase-Frawley; Shrihkande; Villalobos; Borne; Ablordeppey
Journal of Medicinal Chemistry, 2004 , vol. 47, # 3 p. 497 - 508
反应条件
potassium carbonate in water
T=-5°C; 4 h; Yield given;
参考文献
De Ruiter; Andurkar; Riley; Walters; Noggle Jr.
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 4 p. 779 - 786
反应条件
potassium carbonate
T=-5°C; 4 h; Yield given;
参考文献
Finney, Z. Gail; Riley, Thomas N.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 8 p. 895 - 899
反应条件
1: ZnCl2 / toluene / 15 h / Heating
2: NaBH4 / methanol / 1 h / Heating
3: 85 percent / 48percent HBr / 3 h / Heating
View Scheme
参考文献
De Ruiter; Andurkar; Riley; Walters; Noggle Jr.
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 4 p. 779 - 786
Title/Abstract View citing articles Show Details
Finney, Z. Gail; Riley, Thomas N.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 8 p. 895 - 899
