2-氨基-4,5-二甲氧基苯甲酸合成路线 （共 59 条）
反应条件
1: 4 h; Heating; 2: With ammonium hydroxide T=20°C; 4 h; 3: With sodium hydroxide 0.5 h; Heating;
参考文献
Rocco, Silvana A.; Barbarini, Jose Eduardo; Rittner, Roberto
Synthesis, 2004 , # 3 p. 429 - 435
反应条件
thionyl chloride 14 h; Heating;
参考文献
Hinsberger, Stefan; Huesecken, Kristina; Groh, Matthias; Negri, Matthias; Haupenthal, Joerg; Hartmann, Rolf W.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8332 - 8338
反应条件
triethylamine in ethanol
参考文献
Al-Omary, Fatmah A.M.; Hassan, Ghada S.; El-Messery, Shahenda M.; Nagi, Mahmoud N.; Habib, El-Sayed E.; El-Subbagh, Hussein I.
European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 33 - 45
反应条件
1.1: trimethyl orthoformate / methanol / 4 h / 70 °C / |Reflux 2.1: methanesulfonic acid; dl-methionine / 3 h / 130 °C / |Cooling with ice 2.2: pH 7 3.1: pyridine / 3 h / 20 - 100 °C 4.1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 70 °C 5.1: isopropyl alcohol / 5 h / 88 °C View Scheme
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu
Patent: WO2013/71697 A1, 2013 ;
反应条件
1: With sulfuric acid; sodium nitrite in water T=0 - 5°C; 0.5 h; 2: With sulfuric acid; potassium iodide in water T=105°C; 0.5 h; Reflux;
参考文献
WO2012/15875 A1, ;
Page/Page column 57 ;
反应条件
hydrogenchloride; sodium hydroxide
参考文献
Byk Gulden Lomberg Chemische Fabrik Gesellschaft mit beschrankter Haftung
Patent: US3984555 A1, 1976 ;
反应条件
triethylamine in 1,4-dioxane; water T=20°C; 24 h;
参考文献
Asano, Toru; Yoshikawa, Tomohiro; Usui, Taikou; Yamamoto, Hiroshi; Yamamoto, Yoshinori; Uehara, Yoshimasa; Nakamura, Hiroyuki
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 13 p. 3529 - 3542
参考文献
Bridges; Zhou; Cody; Rewcastle; McMichael; Showalter; Fry; Kraker; Denny
Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 267 - 276
参考文献
LeMahieu; Carson; Nason; Parrish; Welton; Baruth; Yaremko
Journal of Medicinal Chemistry, 1983 , vol. 26, # 3 p. 420 - 425
反应条件
in 2-methoxy-ethanol T=125°C; 8 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 43, # 7 p. 1478 - 1488
