2-氨基-4,5-二甲氧基苯甲酸合成路线 （共 59 条）
反应条件
in ethanol
T=20 - 80°C; 4 h; Heating / reflux;
参考文献
Jacobi, Albrecht; Schul, Michael
Patent: US2008/319194 A1, 2008 ;
Location in patent: Page/Page column 5 ;
反应条件
acetic anhydride
1.) dioxane, reflux, 1h, 2.)reflux, 3 h; Yield given. Multistep reaction;
参考文献
Bergman, Jan; Bergman, Solveig
Journal of Organic Chemistry, 1985 , vol. 50, # 8 p. 1246 - 1255
反应条件
1: With hydrogenchloride; sodium nitrite in water
T=5°C; 2 h;
2: With Na2S2 in water
T=20°C;
参考文献
ORION CORPORATION
Patent: WO2007/10085 A2, 2007 ;
Location in patent: Page/Page column 32-33 ;
反应条件
ammonia; benzotriazol-1-ol; dicyclohexyl-carbodiimide in tetrahydrofuran
参考文献
Asano, Toru; Yoshikawa, Tomohiro; Nakamura, Hiroyuki; Uehara, Yoshimasa; Yamamoto, Yoshinori
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 9 p. 2299 - 2302
反应条件
sodium hydroxide in tetrahydrofuran; water
参考文献
American Cyanamid Company
Patent: US5001157 A1, 1991 ;
反应条件
isopentyl nitrite in dichloromethane
T=40°C;
参考文献
Rao, U. Narasimha; Sathunuru, Ramadas; Maguire, John A.; Biehl, Ed
Journal of Heterocyclic Chemistry, 2004 , vol. 41, # 1 p. 13 - 21
反应条件
1.1: sodium nitrite; hydrogenchloride / water / 1 h / 0 °C
1.2: 0 - 90 °C
2.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 0 - 20 °C
3.1: pyridinium chlorochromate; silica gel / dichloromethane / 2 h / 0 - 20 °C
View Scheme
参考文献
Zhou, Ping-Xin; Luo, Jian-Yi; Zhao, Lian-Biao; Ye, Yu-Ying; Liang, Yong-Min
Chemical Communications, 2013 , vol. 49, # 31 p. 3254 - 3256
反应条件
1: 30 percent / POCl3 / 2 h / Heating
2: 77 percent / H2; aq. AcOH / Raney Ni / methanol / 6 h / 20 °C
View Scheme
参考文献
Rosini, Michela; Antonello, Alessandra; Cavalli, Andrea; Bolognesi, Maria L.; Minarini, Anna; Marucci, Gabriella; Poggesi, Elena; Leonardi, Amedeo; Melchiorre, Carlo
Journal of Medicinal Chemistry, 2003 , vol. 46, # 23 p. 4895 - 4903
反应条件
triethylamine in toluene
T=110°C; 15 h;
参考文献
Allendoerfer, Nadine; Es-Sayed, Mazen; Nieger, Martin; Braese, Stefan
Tetrahedron Letters, 2012 , vol. 53, # 4 p. 388 - 391
