2,3-O-异亚丙基-D-来苏糖酸-1,4-内酯合成路线 （共 17 条）
反应条件
1: MeSO3H / acetone / 20 h / 20 °C
2: aq. AcOH / 16.5 h / 28 - 29 °C
View Scheme
参考文献
Godskesen, Michael; Lundt, Inge; Sotofte, Inger
Tetrahedron Asymmetry, 2000 , vol. 11, # 2 p. 567 - 579
反应条件
methanesulfonic acid
T=20°C; 40 h;
参考文献
Fan, Ao; Jaenicke, Stephan; Chuah, Gaik-Khuan
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 22 p. 7720 - 7726
反应条件
1: 1.) t-BuOK / 1.) THF, r.t., 1 h, 2.) -78 to r.t., 3 h
2: PCC, NaOAc, MS 4A / CH2Cl2 / 5 h / Ambient temperature
3: aq. NaH2PO4, NaClO2, 2-methylbut-2-ene / 2-methyl-propan-2-ol / 1.5 h / 25 - 30 °C
4: 94 percent / diethyl ether / 0.5 h / 0 °C
5: 2.7 percent / MCPBA / CH2Cl2 / 12 h / Ambient temperature
View Scheme
参考文献
Rao, B. Venkateswara; Lahiri, Saswata
Journal of Carbohydrate Chemistry, 1996 , vol. 15, # 8 p. 975 - 984
反应条件
1: PCC, NaOAc, MS 4A / CH2Cl2 / 5 h / Ambient temperature
2: aq. NaH2PO4, NaClO2, 2-methylbut-2-ene / 2-methyl-propan-2-ol / 1.5 h / 25 - 30 °C
3: 94 percent / diethyl ether / 0.5 h / 0 °C
4: 2.7 percent / MCPBA / CH2Cl2 / 12 h / Ambient temperature
View Scheme
参考文献
Rao, B. Venkateswara; Lahiri, Saswata
Journal of Carbohydrate Chemistry, 1996 , vol. 15, # 8 p. 975 - 984
反应条件
1: 94 percent / diethyl ether / 0.5 h / 0 °C
2: 2.7 percent / MCPBA / CH2Cl2 / 12 h / Ambient temperature
View Scheme
参考文献
Rao, B. Venkateswara; Lahiri, Saswata
Journal of Carbohydrate Chemistry, 1996 , vol. 15, # 8 p. 975 - 984
反应条件
1: aq. NaH2PO4, NaClO2, 2-methylbut-2-ene / 2-methyl-propan-2-ol / 1.5 h / 25 - 30 °C
2: 94 percent / diethyl ether / 0.5 h / 0 °C
3: 2.7 percent / MCPBA / CH2Cl2 / 12 h / Ambient temperature
View Scheme
参考文献
Rao, B. Venkateswara; Lahiri, Saswata
Journal of Carbohydrate Chemistry, 1996 , vol. 15, # 8 p. 975 - 984
反应条件
1: 2.) hydrogen chloride / 1.) alkaline solution, Humphlett procedure for oxygenation , 2.) i-PrOH
2: 60 percent / anhyd. CuSO4
View Scheme
参考文献
Fleet, George W.J.; Petursson, Sigthor; Campbell, Arthur L.; Mueller, Richard A.; Behling, James R.; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 665 - 666
