1.1: potassium carbonate / acetone; N,N-dimethyl-formamide / 20 h / 60 °C / |Reflux; |Large scale 2.1: sodium methylate / methanol / 10 - 40 °C / |Large scale 2.2: 2.5 h / 10 - 15 °C / |Large scale 3.1: zinc / acetic acid / 20 h / 40 - 45 °C / |Large scale 4.1: hydrogen; palladium 10 on activated carbon / methanol / 96 h / 20 °C / 900.09 Torr / |Large scale 5.1: Bacillus licheniformis protease; sodium hydroxide / aq. phosphate buffer / 9 h / 20 °C / pH 7.5 / |Resolution of racemate; |Enzymatic reaction 6.1: hydrogenchloride / aq. phosphate buffer / 2 h / 100 °C View Scheme

1.1: potassium carbonate / acetone; N,N-dimethyl-formamide / 20 h / 60 °C / |Reflux; |Large scale 2.1: sodium methylate / methanol / 10 - 40 °C / |Large scale 2.2: 2.5 h / 10 - 15 °C / |Large scale 3.1: zinc / acetic acid / 20 h / 40 - 45 °C / |Large scale 4.1: hydrogen; palladium 10 on activated carbon / methanol / 96 h / 20 °C / 900.09 Torr / |Large scale 5.1: Bacillus licheniformis protease; sodium hydroxide / aq. phosphate buffer / 9 h / 20 °C / pH 7.5 / |Resolution of racemate; |Enzymatic reaction 6.1: hydrogenchloride / aq. phosphate buffer / 2 h / 100 °C View Scheme

1.1: potassium carbonate / acetone; N,N-dimethyl-formamide / 20 h / 60 °C / |Reflux; |Large scale 2.1: sodium methylate / methanol / 10 - 40 °C / |Large scale 2.2: 2.5 h / 10 - 15 °C / |Large scale 3.1: zinc / acetic acid / 20 h / 40 - 45 °C / |Large scale 4.1: hydrogen; palladium 10 on activated carbon / methanol / 96 h / 20 °C / 900.09 Torr / |Large scale View Scheme