1: With water; lithium hydroxide hydrate in ethanol T=0 - 20°C; 4 h; 2: With hydrogenchloride in water pH=Ca. 6.8;

1: 1.) NaH / 1.) DMF, 75-85 deg C, 1.5 h, 2.) DMF, 80 deg C, 18 h 2: NaOH / ethanol; H2O / 2 h / Heating View Scheme

1: With potassium hydroxide; NaY zeolite in methanol 12 h; Heating; 2: With sodium hydroxide in methanol 12 h; Heating; Further stages.;

1.1: potassium hydride / tetrahydrofuran / 18 h / 20 °C / |Inert atmosphere 2.1: sodium t-butanolate; palladium 10 on activated carbon / methanol; ethyl acetate / 2 h / 20 °C 3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C / |Inert atmosphere 3.2: 2 h / 20 °C / |Inert atmosphere 4.1: water; lithium hydroxide hydrate / ethanol / 4 h / 0 - 20 °C 4.2: pH Ca. 6.8 View Scheme

1.1: sodium t-butanolate; palladium 10 on activated carbon / methanol; ethyl acetate / 2 h / 20 °C 2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C / |Inert atmosphere 2.2: 2 h / 20 °C / |Inert atmosphere 3.1: water; lithium hydroxide hydrate / ethanol / 4 h / 0 - 20 °C 3.2: pH Ca. 6.8 View Scheme

alkaline solution; water

Behandeln des Reaktionsprodukts mit Alkalilauge;