乙基(6-甲氧基-2-萘基)(氧代)乙酸酯合成路线 （共 6 条）
反应条件
hydrogenchloride; aluminium trichloride in water; nitrobenzene
反应条件
1: 2-methoxy-6-bromo-naphthalene With magnesium in tetrahydrofuran T=20°C; 0.5 h; 2: oxalic acid diethyl ester in tetrahydrofuran T=-78 - 0°C; 5 h;
参考文献
Shimada, Takayoshi; Kobayashi, Yuka; Saigo, Kazuhiko
Tetrahedron Asymmetry, 2005 , vol. 16, # 23 p. 3807 - 3813
反应条件
potassium fluoride; tetrabutyl ammonium fluoride; methyl iodide in tetrahydrofuran T=20°C; 16 h; Inert atmosphere; chemoselective reaction;
参考文献
Metz, Alison E.; Kozlowski, Marisa C.
Journal of Organic Chemistry, 2013 , vol. 78, # 2 p. 717 - 722
反应条件
hydrogen; triethylamine; palladium on activated charcoal in ethyl acetate P=30400 Torr; 8 h; Ambient temperature;
参考文献
Beccalli, Egle; Benincori, Tiziana; Sannicolo, Franco
Journal of Chemical Research, Miniprint, 1990 , # 1 p. 238 - 264
反应条件
1: 17.1 g / AlCl3 / CHCl3 / a.) 10 deg C, 12 h, b.) reflux, 10 min 2: 1.1 g / H2, Et3N / 10percent Pd/C / ethyl acetate / 8 h / 30400 Torr / Ambient temperature View Scheme
参考文献
Journal of Chemical Research, Miniprint, , # 1 p. 238 - 264
反应条件
n-butyllithium 1.) THF, pentane, ether, -100 deg C, 2.) THF, pentane, ether, -100 deg C, 60 min; Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 12 p. 1886 - 1896
