1,5-二氢-4H-吡咯并[3,2-D]嘧啶-4-酮合成路线 (共 21 条)
反应条件
1: With water; potassium hydroxide 40 h; RefluxLarge scale reaction; 2: With acetic acid T=25 - 35°C; pH=6.5 - 7.5; Large scale reaction;
参考文献
Kamath, Vivekanand P.; Juarez-Brambila, Jesus J.; Morris, Christopher B.; Winslow, Christopher D.; Morris Jr., Philip E.
Organic Process Research and Development, 2009 , vol. 13, # 5 p. 928 - 932
反应条件
in ethanol T=100 - 105°C; 16 h;
参考文献
WO2008/63669 A1, ;
Page/Page column 67 ;
WO 2008/063669 A1
反应条件
in ethanol T=110°C; 18 h;
参考文献
WO2008/70507 A2, ;
Page/Page column 150 ;
反应条件
ammonium hydroxide; hydrogen; palladium dichloride in ethanol 5 h; Ambient temperature;
参考文献
Ektova, L. V.; Preobrazhenskaya, M. N.
Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 7 p. 572 - 574
Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 7 p. 860 - 863
反应条件
copper T=320°C; P=15 Torr; 1 h;
参考文献
Sizova, O. S.; Britikova, N. E.; Novitskii, K. Yu.; Shcherbakova, L. I.; Pershin, G. N.; et al.
Pharmaceutical Chemistry Journal, 1982 , vol. 16, # 11 p. 834 - 838
Khimiko-Farmatsevticheskii Zhurnal, 1982 , vol. 16, # 11 p. 1338 - 1343
反应条件
Ra-Ni; hydrazine in methanol; water T=80°C;
参考文献
Shih, Hsiencheng; Cottam, Howard Brinkerhoff; Carson, Dennis Anthony
Chemical and pharmaceutical bulletin, 2002 , vol. 50, # 3 p. 364 - 367
反应条件
1: sodium ethoxide / ethanol / 72 h / 20 °C 2: 11.8 g / ethanol / 16 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 64, # 22 p. 8411 - 8412
反应条件
hydrogenchloride 6 h; Heating;
参考文献
Brakta, Mohamed; Daves, G. Doyle
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 15 p. 1883 - 1884
反应条件
1: 90 percent / potassium hydroxide / 1 h / Ambient temperature 2: 98 percent / H2 / 5percent Pd/C / methanol / 3 h / 1520 Torr / Ambient temperature 3: 85 percent / aq. HCl / methanol; H2O / 4 h / 60 °C 4: 88 percent / aq. HCl / 6 h / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 15 p. 1883 - 1884
反应条件
1: 98 percent / H2 / 5percent Pd/C / methanol / 3 h / 1520 Torr / Ambient temperature 2: 85 percent / aq. HCl / methanol; H2O / 4 h / 60 °C 3: 88 percent / aq. HCl / 6 h / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 15 p. 1883 - 1884