9-氯-9-氧代壬酸甲酯合成路线 （共 42 条）
反应条件
PhCH2Pd(PPh3)2Cl in toluene
T=80°C; Stille coupling; 4 h;
参考文献
Trost; Pinkerton
Journal of Organic Chemistry, 2001 , vol. 66, # 23 p. 7714 - 7722
反应条件
1: in diethyl ether
T=0 - 5°C; 0.166667 h; Cooling with ice;
2: With hydrogen bromide in diethyl ether
1.5 h; Reflux;
参考文献
Wang, Yiqiang; Cherian, Christina; Orr, Steven; Mitchell-Ryan, Shermaine; Hou, Zhanjun; Raghavan, Sudhir; Matherly, Larry H.; Gangjee, Aleem
Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8684 - 8695
反应条件
1: Br2, I2 / SOCl2; dimethylformamide / 4 h / Irradiation
2: 3.5 h / Ambient temperature
3: NaN3 / ethanol / 15 h / Heating
View Scheme
参考文献
Rosowsky; Bader; Kohler; Freisheim; Moran
Journal of Medicinal Chemistry, 1988 , vol. 31, # 7 p. 1338 - 1344
反应条件
1: Br2, I2 / SOCl2; dimethylformamide / 4 h / Irradiation
2: 3.5 h / Ambient temperature
3: NaN3 / ethanol / 15 h / Heating
4: H2, aq. HCl / Pd-C / ethanol / 17 h
View Scheme
参考文献
Rosowsky; Bader; Kohler; Freisheim; Moran
Journal of Medicinal Chemistry, 1988 , vol. 31, # 7 p. 1338 - 1344
反应条件
1: 25.7 percent / SnCl4 / CHCl3 / 6 h / -50 °C
2: hydrazinhydrate, KOH / bis-(2-hydroxy-ethyl) ether / 1 h / Heating
View Scheme
参考文献
Schoedel, Rolf; Spiteller, Gerhard
Helvetica Chimica Acta, 1985 , vol. 68, p. 1624 - 1634
反应条件
1: Br2, I2 / SOCl2; dimethylformamide / 4 h / Irradiation
2: 3.5 h / Ambient temperature
View Scheme
参考文献
Rosowsky; Bader; Kohler; Freisheim; Moran
Journal of Medicinal Chemistry, 1988 , vol. 31, # 7 p. 1338 - 1344
参考文献
Reinheckel,H.
Monatshefte fuer Chemie, 1967 , vol. 98, p. 1437 - 1445
反应条件
in diethyl ether; benzene
2 h; Heating;
参考文献
Dors, Bernhard; Luftmann, Heinrich; Schaefer, Hans J.
Chemische Berichte, 1983 , vol. 116, # 2 p. 761 - 776
反应条件
benzene
Behandeln des Reaktionsprodukts mit wss.-aethanol. Kalilauge;
参考文献
Bergstroem et al.
Acta Chemica Scandinavica (1947-1973), 1952 , vol. 6, p. 1157,1160, 1169
参考文献
Cochrane,C.C.; Harwood,H.J.
Journal of Organic Chemistry, 1961 , vol. 26, p. 1278 - 1282
