1-甲基-1H-吲哚-3-碳酰肼合成路线 （共 7 条）
反应条件
hydrazine hydrate in ethylene glycol
T=105 - 110°C; 24 h;
参考文献
Kelarev, V. I.; Gasanov, S. Sh.; Karakhanov, R. A.; Polivin, Yu. N.; Kuatbekova, K. P.; Panina, M. E.
Journal of Organic Chemistry USSR (English Translation), 1992 , vol. 28, # 12.2 p. 2069 - 2074
Zhurnal Organicheskoi Khimii, 1992 , vol. 28, # 12 p. 2561 - 2568
反应条件
1.1: sodium hydride / tetrahydrofuran / 0.25 h / 10 °C / |Reflux
1.2: 4 h / 20 °C
2.1: hydrazine hydrate
View Scheme
参考文献
Kumar, Dalip; Kumar, N. Maruthi; Noel, Brett; Shah, Kavita
European Journal of Medicinal Chemistry, 2012 , vol. 55, p. 432 - 438
反应条件
1.1: sulfuric acid / 20 h / |Reflux
2.1: sodium hydride / tetrahydrofuran / 0.25 h / 10 °C / |Reflux
2.2: 4 h / 20 °C
3.1: hydrazine hydrate
View Scheme
参考文献
Kumar, Dalip; Kumar, N. Maruthi; Noel, Brett; Shah, Kavita
European Journal of Medicinal Chemistry, 2012 , vol. 55, p. 432 - 438
反应条件
1: 89 percent / 30percent aq. KOH / 0.5 h / Heating
2: 84 percent / H2NNH2*H2O / ethane-1,2-diol / 24 h / 105 - 110 °C
View Scheme
参考文献
Kelarev, V. I.; Gasanov, S. Sh.; Karakhanov, R. A.; Polivin, Yu. N.; Kuatbekova, K. P.; Panina, M. E.
Journal of Organic Chemistry USSR (English Translation), 1992 , vol. 28, # 12.2 p. 2069 - 2074
Zhurnal Organicheskoi Khimii, 1992 , vol. 28, # 12 p. 2561 - 2568
反应条件
1: 89 percent / 30percent aq. KOH / 0.5 h / Heating
2: 84 percent / H2NNH2*H2O / ethane-1,2-diol / 24 h / 105 - 110 °C
View Scheme
参考文献
Kelarev, V. I.; Gasanov, S. Sh.; Karakhanov, R. A.; Polivin, Yu. N.; Kuatbekova, K. P.; Panina, M. E.
Journal of Organic Chemistry USSR (English Translation), 1992 , vol. 28, # 12.2 p. 2069 - 2074
Zhurnal Organicheskoi Khimii, 1992 , vol. 28, # 12 p. 2561 - 2568
反应条件
1: sulfuric acid / ethanol / Reflux
2: hydrazine hydrate / ethanol
View Scheme
参考文献
Kumar, Dalip; Maruthi Kumar; Ghosh, Soumitra; Shah, Kavita
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 212 - 215
反应条件
1.1: N,N-dimethyl-formamide / 3 h / 0 °C
1.2: 12 h / 100 °C
2.1: 10 h / 80 °C / |Acidic conditions
3.1: sodium hydride / N,N-dimethyl-formamide / 3 h / 30 °C
4.1: ethanol; hydrazine hydrate / 12 h / 90 °C
View Scheme
参考文献
Kumar, Dalip; Arun; MaruthiKumar; Acosta, Glen; Noel, Brett; Shah, Kavita
ChemMedChem, 2012 , vol. 7, # 11 p. 1915 - 1920
