5,8-二羟基-1-萘甲酸 gamma-内酯合成路线 （共 7 条）
反应条件
1) EtOH, H2O, 30 min, 2) EtOH, -15 deg C; Yield given. Multistep reaction;
参考文献
Fillion; Porte; Bartoli; Bouaziz; Berlion; Villard
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 2 p. 493 - 495
反应条件
1: With toluene-4-sulfonic acid in toluene
T=120°C; 4 h;
2: With 5 palladium on charcoal in toluene
T=120°C; 12 h;
参考文献
Ferrari, Stefania; Calo, Samuele; Leone, Rosalida; Luciani, Rosaria; Costantino, Luca; Sammak, Susan; Di Pisa, Flavio; Pozzi, Cecilia; Mangani, Stefano; Costi, M. Paola
Journal of Medicinal Chemistry, 2013 , vol. 56, # 22 p. 9356 - 9360
反应条件
palladium on activated charcoal in xylene
Heating;
参考文献
Laharotte; Bouaziz; Rougny; Fillion
Pharmazie, 1986 , vol. 41, # 2 p. 142 - 142
反应条件
phenyl isocyanate; palladium on activated charcoal in xylene
T=140°C; 1 h;
参考文献
Bouaziz, Z.; Laharotte, C.; Rougny, A.; Fillion, H.
Bulletin des Societes Chimiques Belges, 1986 , vol. 95, # 2 p. 143 - 144
反应条件
toluene-4-sulfonic acid; palladium on activated charcoal
1.) toluene, heating, 5 h, 2.) heating, 24 h; Yield given. Multistep reaction;
参考文献
Sabie, R.; Fillion, H.; Daudon, M.; Pinatel, H.
Synthetic Communications, 1990 , vol. 20, # 11 p. 1713 - 1719
反应条件
palladium on activated charcoal in xylene
T=140°C; 1 h;
参考文献
Bouaziz, Z.; Laharotte, C.; Rougny, A.; Fillion, H.
Bulletin des Societes Chimiques Belges, 1986 , vol. 95, # 2 p. 143 - 144
反应条件
1.1: toluene / 24 h / 80 °C
2.1: toluene-4-sulfonic acid / toluene / 4 h / 120 °C
2.2: 12 h / 120 °C
View Scheme
参考文献
Ferrari, Stefania; Calo, Samuele; Leone, Rosalida; Luciani, Rosaria; Costantino, Luca; Sammak, Susan; Di Pisa, Flavio; Pozzi, Cecilia; Mangani, Stefano; Costi, M. Paola
Journal of Medicinal Chemistry, 2013 , vol. 56, # 22 p. 9356 - 9360
