2-(1H-1,2,4-噻唑-1-基)乙酸乙酯合成路线 (共 9 条)
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Ainsworth; Jones
Journal of the American Chemical Society, 1955 , vol. 77, p. 621,623
反应条件
sodium hydroxide in methanol 0.25 h; Ambient temperature;
参考文献
Nagao, Yoshimitsu; Sano, Shigeki; Oxhiai, Masahito; Fujita, Eichi
Tetrahedron, 1990 , vol. 46, # 9 p. 3211 - 3232
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C; 16 h;
参考文献
ORION CORPORATION; LINNANEN, Tero; WOHLFAHRT, Gerd; NANDURI, Srinivas; UJJINAMATADA, Ravi; RAJAGOPALAN, Srinivasan; MUKHERJEE, Subhendu
Patent: WO2013/53983 A1, 2013 ;
Location in patent: Page/Page column 39 ;
反应条件
potassium carbonate in 1,4-dioxane
6 h; Heating;
参考文献
Srivastava; Srivastava, Soumya
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002 , vol. 41, # 9 p. 1937 - 1945
Title/Abstract Full Text View citing articles Show Details
Srivastava; Srivastava, Soumya
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002 , vol. 41, # 11 p. 2357 - 2363
反应条件
in N,N-dimethyl-formamide
T=-10 - 20°C; 20 h;
参考文献
Santhera Pharmaceuticals (Schweiz) AG
Patent: EP2020405 A1, 2009 ;
Location in patent: Page/Page column 47 ;
EP 2020405 A1
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran
T=0 - 20°C; Alkylation;
参考文献
Bulger, Paul G.; Cottrell, Ian F.; Cowden, Cameron J.; Davies, Antony J.; Dolling, Ulf-H.
Tetrahedron Letters, 2000 , vol. 41, # 8 p. 1297 - 1301
反应条件
hydrogenchloride
T=20°C;
参考文献
Woodard, Scott S.; Jerome, Kevin D.
Combinatorial Chemistry and High Throughput Screening, 2011 , vol. 14, # 2 p. 132 - 137
反应条件
ethanol; sodium
Yield given. Multistep reaction;
参考文献
Couture, Axel; Lablache-Combier, Alain; Grandclaudon, Pierre; Surpateanu, Gheorghe
Heterocycles, 1990 , vol. 31, # 12 p. 2111 - 2114
反应条件
sodium ethanolate
1.) EtOH, RT, 2 h, 2.) EtOH, overnight; Yield given. Multistep reaction;
参考文献
Surpateanu, Gheorghe; Lablache-Combier, Alain; Grandclaudon, Pierre; Coutere, Alain; Mouchel, B.
Revue Roumaine de Chimie, 1993 , vol. 38, # 6 p. 671 - 681