1: LiAlH4; (S)-binaphthol / tetrahydrofuran; ethanol / 1 h / -78 °C 2: aq. AcOH / tetrahydrofuran / 2.5 h / 40 °C 3: 1.0 M aq. NaOH / methanol; tetrahydrofuran / 2 h / 20 °C View Scheme

1: 92 percent / (S)-binaphthol, LiAlH4 / ethanol; tetrahydrofuran / -100 - -78 °C 2: 93 percent / acetic acid / H2O; tetrahydrofuran / 40 °C 3: 95 percent / 1N NaOH / methanol; tetrahydrofuran / Ambient temperature View Scheme