2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; copper diacetate in water; acetonitrile T=20°C; 4 h; Green chemistry;

silver nitrate in phosphate buffer Elimination; pH=7;

1: 78 percent / CuI; Et3N / (PPh3)2PdCl2 / acetonitrile / 24 h / 25 - 30 °C 2: pyridine / CH2Cl2 / 10 h / 20 °C 3: 76 percent / CuI; Et3N / tetrahydrofuran / 36 h / Heating 4: 73 percent / AgNO3 / aq. phosphate buffer / pH 7 View Scheme

1: pyridine / CH2Cl2 / 10 h / 20 °C 2: 76 percent / CuI; Et3N / tetrahydrofuran / 36 h / Heating 3: 73 percent / AgNO3 / aq. phosphate buffer / pH 7 View Scheme

1: 76 percent / CuI; Et3N / tetrahydrofuran / 36 h / Heating 2: 73 percent / AgNO3 / aq. phosphate buffer / pH 7 View Scheme

sodium hydroxide in ethanol