2-(4-氯苯氧基)-2-甲基丙酰胺合成路线 （共 8 条）
反应条件
1: nitric acid, acetic anhydide, trifluoroacetic anhydride, / CDCl3 / -60 °C 2: 98 percent / sodium hydride / dimethylformamide View Scheme
参考文献
Clewley, Robin G.; Fischer, Alfred; Henderson, George N.
Canadian Journal of Chemistry, 1989 , vol. 67, p. 1472 - 1479
反应条件
sodium hydroxide in N,N-dimethyl-formamide T=140°C; Green chemistry;
参考文献
Yu, Jianzhong; Zhang, Peizhi; Wu, Jun; Shang, Zhicai
Tetrahedron Letters, 2013 , vol. 54, # 24 p. 3167 - 3170
反应条件
ammonia in diethyl ether
T=-40°C;
参考文献
Clewley, Robin G.; Fischer, Alfred; Henderson, George N.
Canadian Journal of Chemistry, 1989 , vol. 67, p. 1472 - 1479
参考文献
Michniak; Chapman; Seyda
Journal of Pharmaceutical Sciences, 1993 , vol. 82, # 2 p. 214 - 219
反应条件
1: ethanol / anschliessend Erwaermen mit wss. Natronlauge
2: chloroform; thionyl chloride
3: aqueous ammonia
View Scheme
参考文献
Julia
Bulletin de la Societe Chimique de France, 1956 , p. 776,780, 781
反应条件
sodium hydride
1. dioxane, 1h; 2. 100 deg C, 4h; Yield given. Multistep reaction;
参考文献
Coutts, Ian G. C.; Southcott, Mark R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , p. 767 - 771
反应条件
1: 87 percent / BH3*Me2S / tetrahydrofuran / 4 h / Heating
2: 64 percent / pyridine / tetrahydrofuran / 36 h / Ambient temperature
View Scheme
参考文献
Farmaco, Edizione Scientifica, 1983 , vol. 38, # 9 p. 664 - 671
反应条件
N,N'-dimethyl-N,N'-propyleneurea; sodium hydride in N,N-dimethyl-formamide
1 h; Heating;
参考文献
Coutts, Ian G. C.; Southcott, Mark R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , p. 767 - 771
