16alpha-羟基雌酚酮合成路线 （共 33 条）
反应条件
sulfuric acid; water in 1,4-dioxane T=10 - 20°C;
参考文献
RELIANCE LIFE SCIENCES PVT. LTD; SANJAY, Aher; DEBASHISH, Bose; JAGDISH, Kedia; VIJAY, Gangan
Patent: WO2012/32529 A1, 2012 ;
Location in patent: Page/Page column 10 ;
参考文献
Astra Aktiebolag
Patent: US6043236 A1, 2000 ;
反应条件
oxalic acid in tetrahydrofuran; methanol; water T=60 - 70°C; 2 h;
参考文献
VanBrocklin, Henry F.; Carlson, Kathryn E.; Katzenellenbogen, John A.; Welch, Michael J.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 11 p. 1619 - 1629
反应条件
sodium hydroxide in N,N-dimethyl-formamide 1 h;
参考文献
Numazawa, Mitsuteru; Nagaoka, Masao
Journal of Organic Chemistry, 1982 , vol. 47, # 21 p. 4024 - 4029
反应条件
sodium borodeuteride; palladium dichloride in methanol-d1 T=0°C; 6 h;
参考文献
Numazawa; Nagaoka; Ogata
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 2 p. 618 - 622
反应条件
sulfuric acid T=37°C; 8 h;
参考文献
Numazawa, Tohoku; Kimura, Katsuhiko; Nagaoka, Masao
Steroids, 1981 , vol. 38, # 5 p. 557 - 566
反应条件
hydrogenchloride in methanol 1 h; Ambient temperature;
参考文献
Numazawa, Mitsuteru; Mutsumi, Ayako; Ogata, Mieko
Chemical & Pharmaceutical Bulletin, 1988 , vol. 36, # 9 p. 3381 - 3386
反应条件
sodium hydroxide in pyridine; water 11 h; Ambient temperature;
参考文献
Kiesewetter; Katzenellenbogen; Kilbourn; Welch
Journal of Organic Chemistry, 1984 , vol. 49, # 25 p. 4900 - 4905
反应条件
1: 92 percent / p-toluenesulfonic acid monohydrate / diethyl ether; tetrahydrofuran / 1 h 2: 1.) lithium diisopropylamide (LDA), 2.) MoOPH / 1.) THF, -23 deg C, 30 min, 2.) THF, -23 deg C, 1 h 3: 63 percent / oxalic acid / methanol; tetrahydrofuran; H2O / 2 h / 60 - 70 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 11 p. 1619 - 1629
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate 4 h; Ambient temperature;
参考文献
Ikegawa; Fishman
Steroids, 1982 , vol. 39, # 5 p. 557 - 567
