16alpha-羟基雌酚酮合成路线 （共 33 条）
反应条件
1: 560 mg / CrO3 / acetic acid; H2O / 1) 4 deg C, 30 min, 2) r.t., overnight 2: 290 mg / BF3-etherate / acetic acid / Ambient temperature 3: 1.4 g / HgCl2, CaCO3 / acetonitrile; H2O / 0.5 h / Ambient temperature 4: 140 mg / NaBH4 / tetrahydrofuran; methanol; H2O / 0.5 h / 0 °C 5: 11 mg / conc. HCl / methanol / 2 h / 60 °C 6: 21 mg / HgCl2, CaCO3 / acetonitrile; H2O / Heating 7: 4 mg / H2 / 10percent Pd/C / ethyl acetate / 4 h / Ambient temperature View Scheme
参考文献
Steroids, , vol. 39, # 5 p. 557 - 567
反应条件
1: 21 mg / HgCl2, CaCO3 / acetonitrile; H2O / Heating 2: 4 mg / H2 / 10percent Pd/C / ethyl acetate / 4 h / Ambient temperature View Scheme
参考文献
Steroids, , vol. 39, # 5 p. 557 - 567
反应条件
1: 290 mg / BF3-etherate / acetic acid / Ambient temperature 2: 1.4 g / HgCl2, CaCO3 / acetonitrile; H2O / 0.5 h / Ambient temperature 3: 140 mg / NaBH4 / tetrahydrofuran; methanol; H2O / 0.5 h / 0 °C 4: 11 mg / conc. HCl / methanol / 2 h / 60 °C 5: 21 mg / HgCl2, CaCO3 / acetonitrile; H2O / Heating 6: 4 mg / H2 / 10percent Pd/C / ethyl acetate / 4 h / Ambient temperature View Scheme
参考文献
Steroids, , vol. 39, # 5 p. 557 - 567
反应条件
1: 140 mg / NaBH4 / tetrahydrofuran; methanol; H2O / 0.5 h / 0 °C 2: 11 mg / conc. HCl / methanol / 2 h / 60 °C 3: 21 mg / HgCl2, CaCO3 / acetonitrile; H2O / Heating 4: 4 mg / H2 / 10percent Pd/C / ethyl acetate / 4 h / Ambient temperature View Scheme
参考文献
Steroids, , vol. 39, # 5 p. 557 - 567
反应条件
1: 11 mg / conc. HCl / methanol / 2 h / 60 °C 2: 21 mg / HgCl2, CaCO3 / acetonitrile; H2O / Heating 3: 4 mg / H2 / 10percent Pd/C / ethyl acetate / 4 h / Ambient temperature View Scheme
参考文献
Steroids, , vol. 39, # 5 p. 557 - 567
反应条件
1: 1.4 g / HgCl2, CaCO3 / acetonitrile; H2O / 0.5 h / Ambient temperature 2: 140 mg / NaBH4 / tetrahydrofuran; methanol; H2O / 0.5 h / 0 °C 3: 11 mg / conc. HCl / methanol / 2 h / 60 °C 4: 21 mg / HgCl2, CaCO3 / acetonitrile; H2O / Heating 5: 4 mg / H2 / 10percent Pd/C / ethyl acetate / 4 h / Ambient temperature View Scheme
参考文献
Steroids, , vol. 39, # 5 p. 557 - 567
反应条件
air; water in N,N-dimethyl-formamide T=27°C; 48 h; Streptomyces roseochromogenes ATCC 13400; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Steroids, , vol. 55, # 9 p. 390 - 394
反应条件
hydrogen; palladium on activated charcoal in ethanol
参考文献
Chemical and pharmaceutical bulletin, , vol. 15, # 8 p. 1232 - 1238
反应条件
1: aq. H2SO4 / methanol; acetone 2: H2 / Pd-C / ethanol View Scheme
参考文献
Chemical and pharmaceutical bulletin, , vol. 15, # 8 p. 1232 - 1238
反应条件
1: 1.) lithium diisopropylamide (LDA), 2.) MoOPH / 1.) THF, -23 deg C, 30 min, 2.) THF, -23 deg C, 1 h 2: 63 percent / oxalic acid / methanol; tetrahydrofuran; H2O / 2 h / 60 - 70 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 11 p. 1619 - 1629
