16alpha-羟基雌酚酮合成路线 （共 33 条）
反应条件
1: 89 percent / sodium, D2O, pyridine / 2 h / Ambient temperature 2: 68 percent / p-TsOH*H2O / toluene / 7 h / Heating 3: 81 percent / NaBD4, PdCl2 / CH3OD / 6 h / 0 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 32, # 2 p. 618 - 622
反应条件
1: 68 percent / p-TsOH*H2O / toluene / 7 h / Heating 2: 81 percent / NaBD4, PdCl2 / CH3OD / 6 h / 0 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 32, # 2 p. 618 - 622
反应条件
1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 7 - 20 °C 2: water; sulfuric acid / 1,4-dioxane / 10 - 20 °C View Scheme
反应条件
cytochrome P450 1A2; NADPH-generating system in phosphate buffer T=37°C; Oxidation; pH=7.4; 0.25 h; Enzyme kinetics; Further Variations:Reagentstime;
参考文献
Chemical Research in Toxicology, , vol. 11, # 6 p. 659 - 665
反应条件
Tris HCl buffer in methanol T=37°C; 0.166667 h; effect of metal ions and pH; Product distribution;
参考文献
Steroids, , vol. 64, # 4 p. 252 - 258
反应条件
pyridine; sodium hydroxide Ambient temperaturevariat. rk.-time, NaOH conc.; Yield given. Yields of byproduct given;
参考文献
Steroids, , vol. 38, # 5 p. 557 - 566
参考文献
Ferrer; Calzada; Bonet
Steroids, 1990 , vol. 55, # 9 p. 390 - 394
反应条件
trimethylsilyl iodide in chloroform 7 h; Ambient temperature; Yield givenTitle compound not separated from byproducts;
参考文献
Nagaoka, Masao; Nagasawa, Etsuko; Numazawa, Mitsuteru
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 12 p. 1857 - 1861
反应条件
methanol; sodium tris(acetoxy)borohydride in 1,4-dioxane T=20 - 25°C;
参考文献
RELIANCE LIFE SCIENCES PVT. LTD; SANJAY, Aher; DEBASHISH, Bose; JAGDISH, Kedia; VIJAY, Gangan
Patent: WO2012/32529 A1, 2012 ;
Location in patent: Page/Page column 10 ;
反应条件
trimethylsilyl iodide in chloroform 7 h; Ambient temperature; Yield givenTitle compound not separated from byproducts;
参考文献
Nagaoka, Masao; Nagasawa, Etsuko; Numazawa, Mitsuteru
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 12 p. 1857 - 1861
