2-甲基-1,4-二氢喹啉-4-酮合成路线 （共 33 条）
反应条件
in diphenylether T=255°C; 0.5 h;
参考文献
Bristol-Myers Squibb Company
Patent: US2009/18163 A1, 2009 ;
Location in patent: Page/Page column 24-25 ;
US 20090018163 A1
反应条件
acidic styrol NKC-9 resin in neat (no solvent) T=20°C; Combes Quinoline Synthesis; 0.025 h; Microwave irradiation; Reagent/catalystConcentrationTemperatureTime;
参考文献
Yuan, Shizhen; Zhang, Kehua; Xia, Jingjing
Asian Journal of Chemistry, 2013 , vol. 25, # 10 p. 5535 - 5538
反应条件
hydrogen; Raney nickel W-1 in methanol P=3952 Torr; 3.5 h;
参考文献
Sakamoto, Takao; Kondo, Yoshinori; Uchiyama, Daishi; Yamanaka, Hiroshi
Tetrahedron, 1991 , vol. 47, # 28 p. 5111 - 5118
反应条件
1: With toluene-4-sulfonic acid in hexane 5 h; Reflux; 2: in diphenylether T=260°C; 0.5 h;
参考文献
Chemistry and Biology, , vol. 19, # 3 p. 381 - 390
反应条件
lithium diisopropyl amide in tetrahydrofuran 0 deg C to room temp., 8-12 h;
参考文献
Chong, R.J.; Siddiqui, M.A.; Snieckus, V.
Tetrahedron Letters, 1986 , vol. 27, # 44 p. 5323 - 5326
反应条件
lithium diisopropyl amide in tetrahydrofuran 0 deg C to room temp., 8-12 h;
参考文献
Chong, R.J.; Siddiqui, M.A.; Snieckus, V.
Tetrahedron Letters, 1986 , vol. 27, # 44 p. 5323 - 5326
反应条件
1: 90 percent / Pd(PPh3)2Cl2 / dioxane / 20 h / Heating 2: 63 percent / H2 / Raney nickel W-1 / methanol / 3.5 h / 3952 Torr View Scheme
参考文献
Tetrahedron, , vol. 47, # 28 p. 5111 - 5118
反应条件
in various solvent(s) 4 h; Heating;
参考文献
Flitsch, Wilhelm; Jones, R. Alan; Hohenhorst, Manfred
Tetrahedron Letters, 1987 , vol. 28, # 38 p. 4397 - 4398
反应条件
1: 95 percent / Ambient temperature; for 2-7 days 2: 45 percent / LDA / tetrahydrofuran / 0 deg C to room temp., 8-12 h View Scheme
参考文献
Tetrahedron Letters, , vol. 27, # 44 p. 5323 - 5326
反应条件
1: 95 percent / Ambient temperature; for 2-7 days 2: 55 percent / LDA / tetrahydrofuran / 0 deg C to room temp., 8-12 h View Scheme
参考文献
Tetrahedron Letters, , vol. 27, # 44 p. 5323 - 5326
