4-苯基-2-氮杂环丁酮合成路线 （共 52 条）
反应条件
ethylmagnesium bromide in diethyl ether T=0 - 20°C; 14 h;
参考文献
Monatshefte fur Chemie, , vol. 134, # 3 p. 343 - 354
反应条件
1: toluene / Heating 2: 79 percent / tris(trimethylsilyl)silane; AIBN / toluene / 2 h / 100 °C View Scheme
参考文献
Organic Letters, , vol. 2, # 8 p. 1077 - 1079
反应条件
1: triethylamine / dichloromethane / 4 h / 20 °C 2: palladium diacetate; silver(I) acetate; pentafluorophenyl iodide / 20 - 160 °C / |Sealed tube; |Microwave irradiation 3: ammonium cerium (IV) nitrate / water; acetonitrile / 1 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 16, # 2 p. 480 - 483
反应条件
hydrogenchloride Ambient temperature; Yield given;
参考文献
Journal of the American Chemical Society, , vol. 106, # 17 p. 4819 - 4825
反应条件
1: 54 percent / diethyl ether / 48 h / Heating 2: 98 percent / Zn/Cu / tetrahydrofuran View Scheme
参考文献
Journal of Organic Chemistry, , vol. 50, # 2 p. 169 - 175
反应条件
1: 100 percent / triethylamine / tetrahydrofuran / 1 h / 0 °C 2: 57 percent / potassium t-butoxide / 2-methyl-propan-2-ol; tetrahydrofuran / 1 h / Ambient temperature 3: 96 percent / ceric ammonium nitrate / H2O; acetonitrile / 1 h / Ambient temperature 4: 73 percent / Na, NH3 liq. / tetrahydrofuran / 0.5 h / -78 °C View Scheme
参考文献
Journal of Chemical Research, Miniprint, , # 9 p. 2018 - 2031
反应条件
1: 96 percent / ceric ammonium nitrate / H2O; acetonitrile / 1 h / Ambient temperature 2: 73 percent / Na, NH3 liq. / tetrahydrofuran / 0.5 h / -78 °C View Scheme
参考文献
Journal of Chemical Research, Miniprint, , # 9 p. 2018 - 2031
反应条件
1: 57 percent / potassium t-butoxide / 2-methyl-propan-2-ol; tetrahydrofuran / 1 h / Ambient temperature 2: 96 percent / ceric ammonium nitrate / H2O; acetonitrile / 1 h / Ambient temperature 3: 73 percent / Na, NH3 liq. / tetrahydrofuran / 0.5 h / -78 °C View Scheme
参考文献
Journal of Chemical Research, Miniprint, , # 9 p. 2018 - 2031
反应条件
Cu(I)Br*SMe2 1.) ether, -20 degC, 15 min; 2.) -50 degC, 30 min; Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 26, # 5 p. 547 - 550
反应条件
Yield given. Multistep reaction;
参考文献
Tetrahedron, , vol. 44, # 13 p. 4157 - 4172
