(S)-2-氨基-1-苯乙醇合成路线 （共 64 条）
反应条件
1: K2CO3 / methanol / 1 h / 4 °C 2: NaN3 3: 127 mg / H2 / PtO2 / methanol / 2 h / 20 °C / 750.06 Torr View Scheme
参考文献
Chemistry - A European Journal, , vol. 10, # 15 p. 3673 - 3684
反应条件
LiAlH in tetrahydrofuran 1.) reflux, 8 h, 2.) r.t., overnight;
参考文献
Wu, Shao-Yong; Hirashima, Akinori; Takeya, Ryuko; Eto, Morifusa
Agricultural and Biological Chemistry, 1989 , vol. 53, # 1 p. 165 - 174
反应条件
ammonium hydroxide microwave irradiation;
参考文献
Tetrahedron Asymmetry, , vol. 17, # 3 p. 372 - 376
反应条件
sodium hydroxide in ethanol Heating;
参考文献
Kamal, Ahmed; Khanna, G.B. Ramesh; Krishnaji; Ramu
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 3 p. 613 - 615
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 1) 4h reflux 2) r.t.;
参考文献
Meyers, A. I.; Slade, Joel
Journal of Organic Chemistry, 1980 , vol. 45, # 14 p. 2785 - 2791
反应条件
1: (R)-proline / dimethylsulfoxide / -20 °C 2: NaBH4 / methanol; dimethylsulfoxide / 0.17 h / 0 °C 3: CuSO4*H2O / methanol / 0 °C 4: pyridine / CH2Cl2 / 12 h / 0 °C 5: K2CO3 / methanol / 1 h / 4 °C 6: NaN3 7: 127 mg / H2 / PtO2 / methanol / 2 h / 20 °C / 750.06 Torr View Scheme
参考文献
Chemistry - A European Journal, , vol. 10, # 15 p. 3673 - 3684
反应条件
1: CuSO4*H2O / methanol / 0 °C 2: pyridine / CH2Cl2 / 12 h / 0 °C 3: K2CO3 / methanol / 1 h / 4 °C 4: NaN3 5: 127 mg / H2 / PtO2 / methanol / 2 h / 20 °C / 750.06 Torr View Scheme
参考文献
Chemistry - A European Journal, , vol. 10, # 15 p. 3673 - 3684
反应条件
chiral stationary phase including isopropyl-functionalized CF6 in methanol; acetic acid; triethylamine; acetonitrile T=20°C; Purification / work up;
参考文献
WO2010/148191 A2, ;
Page/Page column 45-49; 58 ;
反应条件
hydrogen; palladium on activated charcoal in methanol Title compound not separated from byproducts.;
参考文献
Journal of Organic Chemistry, , vol. 67, # 5 p. 1712 - 1715
反应条件
pyridoxal 5'-phosphate in dimethyl sulfoxide T=20°C; 89 h; Enzymatic reaction; Title compound not separated from byproducts.;
参考文献
Advanced Synthesis and Catalysis, , vol. 349, # 8-9 p. 1379 - 1386
