2-(4-吡啶基)-2-丙胺合成路线 （共 2 条）
反应条件
1: methyllithium With cerium(III) chloride in tetrahydrofuran; diethyl ether T=-78°C; 0.5 h; Inert atmosphere; 2: 4-pyridinecarbonitrile in tetrahydrofuran; diethyl ether T=-78 - 20°C; 4 h; Inert atmosphere;
参考文献
Jaudzems, Kristaps; Tars, Kaspars; Maurops, Gundars; Ivdra, Natalija; Otikovs, Martins; Leitans, Janis; Kanepe-Lapsa, Iveta; Domraceva, Ilona; Mutule, Ilze; Trapencieris, Peteris; Blackman, Michael J.; Jirgensons, Aigars
ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 4 p. 373 - 377
反应条件
1: in tetrahydrofuran; diethyl ether T=100°C; Double Grignard addition; 0.166667 h; Microwave irradiation; 2: With titanium(IV) isopropylate in tetrahydrofuran; diethyl ether T=50°C; Double Grignard addition; 1 h; Microwave irradiation;
参考文献
Tetrahedron Letters, , vol. 50, # 50 p. 7070 - 7073
