2-[4-(甲基氨基)苯基]-1,3-苯并噻唑-6-醇合成路线 （共 7 条）
反应条件
boron tribromide in dichloromethane; water
T=20°C; 12 h;
参考文献
Chi, Dae-Yoon; Lee, Byoung-Se; Uthaiwan, Sirion; Chu, So-Young; Bae, Yu-Jin; Park, Chansoo; Moon, Dae-Hyuk; Ryu, Jin-Sook; Kim, Jae-Seung; Oh, Seung-Jun
Patent: US2012/214994 A1, 2012 ;
Location in patent: Page/Page column 14 ;
反应条件
boron tribromide in dichloromethane
16 h;
参考文献
Zheng, Ming-Qiang; Yin, Duan-Zhi; Qiao, Jin-Ping; Zhang, Lan; Wang, Yong-Xian
Journal of Fluorine Chemistry, 2008 , vol. 129, # 3 p. 210 - 216
反应条件
1: 15.3 g / aq. KOH / ethane-1,2-diol / 48 h / Heating
2: 21 percent / polyphosphoric acid / 1.5 h / 170 °C
3: 75 percent / BBr3 / CH2Cl2 / 16 h / 20 °C
View Scheme
参考文献
Mathis, Chester A; Wang, Yanming; Holt, Daniel P; Huang, Guo-Feng; Debnath, Manik L; Klunk, William E
Journal of medicinal chemistry, 2003 , vol. 46, # 13 p. 2740 - 2754
反应条件
1: 21 percent / polyphosphoric acid / 1.5 h / 170 °C
2: 75 percent / BBr3 / CH2Cl2 / 16 h / 20 °C
View Scheme
参考文献
Mathis, Chester A; Wang, Yanming; Holt, Daniel P; Huang, Guo-Feng; Debnath, Manik L; Klunk, William E
Journal of medicinal chemistry, 2003 , vol. 46, # 13 p. 2740 - 2754
反应条件
1.1: Lawesson's reagent / chlorobenzene / 6 h / Reflux
2.1: sodium hydroxide; K3Fe(CN)6 / ethanol; water / 1 h / 90 °C
3.1: tin(ll) chloride / ethanol / 4 h / Reflux; Inert atmosphere
4.1: sodium methylate / methanol / 4 h / 20 °C
4.2: 1.5 h / Reflux
5.1: boron tribromide / dichloromethane; water / 12 h / 20 °C
View Scheme
参考文献
Chi, Dae-Yoon; Lee, Byoung-Se; Uthaiwan, Sirion; Chu, So-Young; Bae, Yu-Jin; Park, Chansoo; Moon, Dae-Hyuk; Ryu, Jin-Sook; Kim, Jae-Seung; Oh, Seung-Jun
Patent: US2012/214994 A1, 2012 ;
反应条件
1.1: pyridine / 2 h / 100 °C
2.1: Lawesson's reagent / chlorobenzene / 6 h / Reflux
3.1: sodium hydroxide; K3Fe(CN)6 / ethanol; water / 1 h / 90 °C
4.1: tin(ll) chloride / ethanol / 4 h / Reflux; Inert atmosphere
5.1: sodium methylate / methanol / 4 h / 20 °C
5.2: 1.5 h / Reflux
6.1: boron tribromide / dichloromethane; water / 12 h / 20 °C
View Scheme
参考文献
Chi, Dae-Yoon; Lee, Byoung-Se; Uthaiwan, Sirion; Chu, So-Young; Bae, Yu-Jin; Park, Chansoo; Moon, Dae-Hyuk; Ryu, Jin-Sook; Kim, Jae-Seung; Oh, Seung-Jun
Patent: US2012/214994 A1, 2012 ;
反应条件
1.1: pyridine / 2 h / 100 °C
2.1: Lawesson's reagent / chlorobenzene / 6 h / Reflux
3.1: sodium hydroxide; K3Fe(CN)6 / ethanol; water / 1 h / 90 °C
4.1: tin(ll) chloride / ethanol / 4 h / Reflux; Inert atmosphere
5.1: sodium methylate / methanol / 4 h / 20 °C
5.2: 1.5 h / Reflux
6.1: boron tribromide / dichloromethane; water / 12 h / 20 °C
View Scheme
参考文献
Chi, Dae-Yoon; Lee, Byoung-Se; Uthaiwan, Sirion; Chu, So-Young; Bae, Yu-Jin; Park, Chansoo; Moon, Dae-Hyuk; Ryu, Jin-Sook; Kim, Jae-Seung; Oh, Seung-Jun
Patent: US2012/214994 A1, 2012 ;
