6-溴-2-(4-硝基苯基)苯并噻唑合成路线 （共 7 条）
反应条件
in dimethyl sulfoxide
T=180°C; 0.5 h;
参考文献
Lee, Byung Chul; Kim, Ji Sun; Kim, Bom Sahn; Son, Ji Yeon; Hong, Soo Kyung; Park, Hyun Soo; Moon, Byung Seok; Jung, Jae Ho; Jeong, Jae Min; Kim, Sang Eun
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 9 p. 2980 - 2990
反应条件
sodium hydroxide; potassium hexacyanoferrate(III) in ethanol
T=80 - 90°C; 0.5 h;
参考文献
Mathis, Chester A; Wang, Yanming; Holt, Daniel P; Huang, Guo-Feng; Debnath, Manik L; Klunk, William E
Journal of medicinal chemistry, 2003 , vol. 46, # 13 p. 2740 - 2754
反应条件
in tetrahydrofuran; dimethylsulfoxide (DMSO); water
参考文献
SNU RandDB FOUNDATION
Patent: US2011/250136 A1, 2011 ;
反应条件
1: 71 percent / Lawesson's reagent / chlorobenzene / 6 h / 120 °C
2: 35 percent / aq. NaOH; K3Fe(CN)6 / ethanol / 0.5 h / 80 - 90 °C
View Scheme
参考文献
Mathis, Chester A; Wang, Yanming; Holt, Daniel P; Huang, Guo-Feng; Debnath, Manik L; Klunk, William E
Journal of medicinal chemistry, 2003 , vol. 46, # 13 p. 2740 - 2754
反应条件
1: 86 percent / benzene / 23 h / 20 °C
2: 71 percent / Lawesson's reagent / chlorobenzene / 6 h / 120 °C
3: 35 percent / aq. NaOH; K3Fe(CN)6 / ethanol / 0.5 h / 80 - 90 °C
View Scheme
参考文献
Mathis, Chester A; Wang, Yanming; Holt, Daniel P; Huang, Guo-Feng; Debnath, Manik L; Klunk, William E
Journal of medicinal chemistry, 2003 , vol. 46, # 13 p. 2740 - 2754
反应条件
1: 86 percent / benzene / 23 h / 20 °C
2: 71 percent / Lawesson's reagent / chlorobenzene / 6 h / 120 °C
3: 35 percent / aq. NaOH; K3Fe(CN)6 / ethanol / 0.5 h / 80 - 90 °C
View Scheme
参考文献
Mathis, Chester A; Wang, Yanming; Holt, Daniel P; Huang, Guo-Feng; Debnath, Manik L; Klunk, William E
Journal of medicinal chemistry, 2003 , vol. 46, # 13 p. 2740 - 2754
反应条件
ethanol; tin(ll) chloride
T=100°C; 1 h; Inert atmosphere;
参考文献
SNU Randamp;DB FOUNDATION; KIM, Sang Eun; LEE, Byung Chul; KIM, Ji Sun; CHUN, Young Sin
Patent: WO2010/53218 A1, 2010 ;
Location in patent: Page/Page column 30; 31 ;
