1-(4-氟苯基)-5-氧代吡咯烷-3-羧酸合成路线 （共 3 条）
参考文献
Watanabe, S.; Ogawa, K.; Ohno, T.; Yano, S.; Yamada, H.; Shirasaka, T.
European Journal of Medicinal Chemistry, 1994 , vol. 29, # 9 p. 675 - 686
反应条件
1.1: thionyl chloride / 1,2-dichloro-ethane / 1 h / 80 °C 2.1: ammonia / water; tetrahydrofuran / 1 h / 20 °C 3.1: [bis(acetoxy)iodo]benzene / water; tetrahydrofuran 3.2: pH 2 View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; LIN, Xianfeng; QIU, Zongxing; TANG, Guozhi; WONG, Jason Christopher; ZHANG, Zhenshan
Patent: WO2012/98132 A1, 2012 ;
WO 2012/098132 A1
反应条件
1.1: thionyl chloride / 1,2-dichloro-ethane / 1 h / 80 °C
2.1: ammonia / water; tetrahydrofuran / 1 h / 20 °C
3.1: [bis(acetoxy)iodo]benzene / water; tetrahydrofuran
3.2: pH 2
View Scheme
参考文献
Lin, Xianfeng; Qiu, Zongxing; Tang, Guozhi; Wong, Jason Christopher; Zhang, Zhenshan
Patent: US2012/190700 A1, 2012 ;
