N-(3-甲氧基苯基)-2,2-二甲基丙酰胺合成路线 （共 24 条）
反应条件
sec.-butyllithium in tetrahydrofuran; hexane 1.) 0 deg C, 2 h, 2.) 0 deg C, 1 h; r.t., 12 h;
参考文献
Ubeda, J. Ignacio; Villacampa, Mercedes; Avendano, Carmen
Synthesis, 1998 , # 8 p. 1176 - 1180
反应条件
1: 1.) n-BuLi, 2.) hexachloroethane / 1.) THF, 0 deg C, 2 h, 2.) THF, from 0 deg C to RT, overnight 2: conc. HCl / ethanol / 6 h / Heating View Scheme
参考文献
Shutske, Gregory M.; Allen, Richard C.; Foersch, Manfred F.; Setescak, Linda L.; Wilker, Jeffrey C.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 9 p. 1307 - 1311
反应条件
1: sec-BuLi / tetrahydrofuran; hexane / 1.) 0 deg C, 2 h, 2.) 0 deg C, 1 h; r.t., 12 h 2: KHMDS / tetrahydrofuran; hexane; toluene / 1.) 0 deg C, 10 min, 2.) r.t., 2 h View Scheme
参考文献
Ubeda, J. Ignacio; Villacampa, Mercedes; Avendano, Carmen
Synthesis, 1998 , # 8 p. 1176 - 1180
反应条件
Yield given. Multistep reaction;
参考文献
Cho; Gong; Muchowski
Journal of Organic Chemistry, 1991 , vol. 56, # 26 p. 7288 - 7291
反应条件
Yield given. Multistep reaction;
参考文献
Cho; Gong; Muchowski
Journal of Organic Chemistry, 1991 , vol. 56, # 26 p. 7288 - 7291
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 0 °C 1.2: -78 - 20 °C 1.3: -78 - 20 °C 2.1: hydrogenchloride; water / 1,4-dioxane / 6 h / Reflux 3.1: sodium nitrite / 1,4-dioxane / -5 °C 3.2: -5 - 80 °C View Scheme
参考文献
Cui, Jian-Fang; Huang, Hui; Wong, Henry N. C.
Synlett, 2011 , # 7 p. 1018 - 1022
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 12 h / 0 °C 1.2: 90 percent / 1,2-dibromoethane / tetrahydrofuran; hexane / -78 - 20 °C 2.1: aq. HCl / dioxane / 3 h / Heating View Scheme
参考文献
Ooi, Takashi; Takahashi, Makoto; Yamada, Masao; Tayama, Eiji; Omoto, Kiyoyuki; Maruoka, Keiji
Journal of the American Chemical Society, 2004 , vol. 126, # 4 p. 1150 - 1160
反应条件
1: sec-BuLi / tetrahydrofuran; hexane / 1.) 0 deg C, 2 h, 2.) 0 deg C, 1 h; r.t., 12 h 2: KHMDS / tetrahydrofuran; hexane; toluene / 2 h / Ambient temperature View Scheme
参考文献
Synthesis, , # 8 p. 1176 - 1180
反应条件
sec.-butyllithium; potassium hexamethylsilazane 1.) THF, 0 deg C, 2 h; 2.) THF, 0 deg C, 1 h; 3.) 0 deg C, 10 min; RT, 2h; Yield given. Multistep reaction;
参考文献
Synlett, , vol. 1997, # 3 p. 285 - 286
反应条件
Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 56, # 26 p. 7288 - 7291
