2-苯乙基-1,3-二恶烷合成路线 （共 7 条）
反应条件
N,N,N',N,-tetramethylethylenediamine; ((Me)N2N)Ni-Cl in tetrahydrofuran
T=20°C; Kumada-Corriu-Tamao coupling reaction; 2 h; Inert atmosphere;
参考文献
Vechorkin, Oleg; Proust, Valerie; Hu, Xile
Journal of the American Chemical Society, 2009 , vol. 131, # 28 p. 9756 - 9766
反应条件
acetonyl(triphenylphosphonium) bromide in dichloromethane
T=20°C; 1 h;
参考文献
Hon, Yung-Son; Lee, Chia-Fu; Chen, Rong-Jiunn; Huang, Yi-Fen
Synthetic Communications, 2003 , vol. 33, # 16 p. 2829 - 2842
反应条件
1,1-dimethylpropan-1-ol; ((Me)N2N)Ni-Cl; sodium iodide; sodium hydroxide in 1,4-dioxane
T=80°C; Suzuki-Miyaura Coupling; 24 h; Inert atmosphere;
参考文献
Di Franco, Thomas; Boutin, Nicolas; Hu, Xile
Synthesis (Germany), 2013 , vol. 45, # 21 art. no. SS-2013-Z0609-FA, p. 2949 - 2958
反应条件
1: With Nitrous oxide in tetrahydrofuran
T=0°C; 0.0833333 h; GloveboxSchlenk technique;
2: With dilithium tetrachlorocuprate in tetrahydrofuran
T=0 - 20°C; 18 h; Schlenk techniqueGlovebox;
参考文献
Kiefer, Gregor; Jeanbourquin, Loic; Severin, Kay
Angewandte Chemie - International Edition, 2013 , vol. 52, # 24 p. 6302 - 6305
Angew. Chem., 2013 , vol. 125, # 24 p. 6422 - 6425
反应条件
1: diethyl ether; tetrahydrofuran / -50 - 20 °C / |Inert atmosphere; |Schlenk technique
2: sodium hydroxide; ((Me)N2N)Ni-Cl; sodium iodide; 1,1-dimethylpropan-1-ol / 1,4-dioxane / 24 h / 80 °C / |Inert atmosphere
View Scheme
参考文献
Di Franco, Thomas; Boutin, Nicolas; Hu, Xile
Synthesis (Germany), 2013 , vol. 45, # 21 art. no. SS-2013-Z0609-FA, p. 2949 - 2958
反应条件
1: sodium hydride / tetrahydrofuran; mineral oil / 4 h / 0 - 20 °C / |Inert atmosphere
2: carbonylchlorohydridetris(triphenylphosphine) ruthenium(II); phosphoric acid diphenyl ester / toluene / 24 h / 20 - 115 °C / |Inert atmosphere
View Scheme
参考文献
Ascic, Erhad; Ohm, Ragnhild G.; Petersen, Rico; Hansen, Mette R.; Hansen, Casper L.; Madsen, Daniel; Tanner, David; Nielsen, Thomas E.
Chemistry - A European Journal, 2014 , vol. 20, # 12 p. 3297 - 3300
反应条件
copper(l) iodide; magnesium
1) THF, 30 deg C, 10 min; 2) THF, 15 h, 25 deg C; Yield given. Multistep reaction;
参考文献
Lee, Yuh-Shan; Valle ,Luis del; Larson, Gerald L.
Synthetic Communications, 1987 , vol. 17, # 4 p. 385 - 392
