2,2-二甲基-3-氯-3-丁烯酸甲酯合成路线 （共 6 条）
反应条件
1: With sodium hydroxide; water 5 h; Heating / reflux; 2: With hydrogenchloride in water
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: NaOH / H2O 2: NaNH2 / dimethylsulfoxide View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: NaOH / H2O 2: NaNH2 / dimethylsulfoxide 4: Irradiation View Scheme
参考文献
Schexnayder,M.A.; Engel,P.S.
Journal of the American Chemical Society, 1975 , vol. 97, p. 4825 - 4836
反应条件
phosphorus pentachloride; N,N-dimethyl-formamide in dichloromethane
T=0°C; Reflux;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; RUAH, Sara, Hadida, S.; GROOTENHUIS, Peter, D., J.; VAN GOOR, Fredrick; MILLER, Mark, T.; MCCARTNEY, Jason; ZHOU, Jinglan; BEAR, Brian; NUMA, Mehdi, Michel, Djamel
Patent: WO2010/53471 A1, 2010 ;
Location in patent: Page/Page column 58-59 ;
反应条件
phosphorus pentachloride; N,N-dimethyl-formamide in dichloromethane
参考文献
Schexnayder,M.A.; Engel,P.S.
Journal of the American Chemical Society, 1975 , vol. 97, p. 4825 - 4836
反应条件
1: methyl iodide / tetrahydrofuran
2: phosphorus pentachloride / dichloromethane; N,N-dimethyl-formamide
View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
