4-氧杂-4,5,6,7-四氢苯并[B]呋喃-3-羧酸合成路线 （共 18 条）
参考文献
Sakai, Makiko
Heterocycles, 1982 , vol. 19, # 5 p. 829 - 835
反应条件
anhydrous ammonium carbonate; potassium hydroxide 1) diethylene glycol, 120-130 deg C, 1h, 2) 195 deg C, 3h; Yield given. Multistep reaction;
参考文献
Berg, E. M. M. van den; Jansen, F. J. H. M.; Goede, A. T. J. W. de; Baldew, A. U.; Lugtenburg, J.
Recueil des Travaux Chimiques des Pays-Bas, 1990 , vol. 109, # 4 p. 287 - 297
反应条件
anhydrous ammonium carbonate; hexan-1-ol T=120 - 130°C; 1 h;
参考文献
Berg, E. M. M. van den; Jansen, F. J. H. M.; Goede, A. T. J. W. de; Baldew, A. U.; Lugtenburg, J.
Recueil des Travaux Chimiques des Pays-Bas, 1990 , vol. 109, # 4 p. 287 - 297
反应条件
in ethanol; water T=120°C; P=10343.2 Torr; 0.166667 h; microwave irradiation;
参考文献
Piras, Leonarda; Ghiron, Chiara; Minetto, Giacomo; Taddei, Maurizio
Tetrahedron Letters, 2008 , vol. 49, # 3 p. 459 - 462
反应条件
potassium carbonate; caesium carbonate in N,N-dimethyl-formamide T=60°C; 2 h;
参考文献
Neurogen Corporation
Patent: US2005/14939 A1, 2005 ;
Location in patent: Page 23 ;
US 20050014939 A1
参考文献
Neurogen Corporation
Patent: US5750702 A1, 1998 ;
US 5750702 A
反应条件
1: 1) ammonium carbonate, 2) KOH / 1) diethylene glycol, 120-130 deg C, 1h, 2) 195 deg C, 3h 2: 1a) BuLi / 1a) THF, hexane, -70 deg C, 1b) 0 deg C, 1h, 2) THF, -40 deg C 3: 60 percent / DDQ / toluene / 85 °C / one night 4: 85 percent Chromat. / 3M NaOH / ethanol / 0.5 h / 0 °C View Scheme
参考文献
Berg, E. M. M. van den; Jansen, F. J. H. M.; Goede, A. T. J. W. de; Baldew, A. U.; Lugtenburg, J.
Recueil des Travaux Chimiques des Pays-Bas, 1990 , vol. 109, # 4 p. 287 - 297
反应条件
dodec-1-ene; palladium on activated charcoal in decalin 20 h; Heating;
参考文献
Kneen, Geoffrey; Maddocks, Peter J.
Synthetic Communications, 1986 , vol. 16, # 13 p. 1635 - 1640
