5-溴-2,4-二甲氧基嘧啶合成路线 （共 22 条）
反应条件
bromine; sodium hydrogencarbonate in methanol; water T=25°C;
参考文献
Boudet, Nadege; Dubbaka, Srinivas Reddy; Knochel, Paul
Organic Letters, 2008 , vol. 10, # 9 p. 1715 - 1718
反应条件
in tetrahydrofuran T=20°C;
参考文献
WO2007/113232 A1, ;
Page/Page column 106-107 ;
反应条件
bromine; potassium bromide in water T=60 - 80°C; 0.75 h;
参考文献
Skul'ski, L.; Kuyava, A.; Vrochin'ski, P.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1989 , vol. 25, # 2 p. 205 - 208
Khimiya Geterotsiklicheskikh Soedinenii, 1989 , # 2 p. 249 - 252
反应条件
bromine; potassium bromide in water T=60 - 80°C; 0.75 h;
参考文献
Skul'ski, L.; Kuyava, A.; Vrochin'ski, P.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1989 , vol. 25, # 2 p. 205 - 208
Khimiya Geterotsiklicheskikh Soedinenii, 1989 , # 2 p. 249 - 252
参考文献
Journal of the American Chemical Society, , vol. 56, p. 134,138
参考文献
Journal of the American Chemical Society, , vol. 56, p. 134,138
反应条件
1: methanol With sodium 2: 5-Bromo-2,4-dichloror-pyrimidine 2 h; Reflux;
参考文献
Synthetic Communications, , vol. 40, # 13 p. 1939 - 1943
反应条件
1: 5-bromo-2,4-dimethoxy-pyrimidine With magnesium; ethylene dibromide in tetrahydrofuran 3 h; RefluxInert atmosphere; 2: 7,14-dioxa-1-azaspirolt;4.2.5.2gt;pentadec-1-ene 1-oxide in tetrahydrofuran T=-10 - 20°C; Inert atmosphere; 3: With ammonia; copper diacetate in 1,4-dioxane; dichloromethane; water T=20°C; 24 h;
参考文献
Tetrahedron Letters, , vol. 52, # 16 p. 1866 - 1870
反应条件
1: 5-bromo-2,4-dimethoxy-pyrimidine With tert.-butyl lithium in tetrahydrofuran; pentane T=-78°C; 0.5 h; Inert atmosphere; 2: 7,14-dioxa-1-azaspirolt;4.2.5.2gt;pentadec-1-ene 1-oxide in tetrahydrofuran; pentane T=-78 - 20°C; Inert atmosphere; 3: With ammonia; copper diacetate in 1,4-dioxane; dichloromethane; water T=20°C; 24 h;
参考文献
Tetrahedron Letters, , vol. 52, # 16 p. 1866 - 1870
反应条件
n-butyllithium 1.) hexane, ether, -70 deg C, 2.) hexane , ether, a.) -70 deg C, 1.5 h, b.) 4 d; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Coe, Paul L.; Harnden, Michael R.; Jones, A. Stanley; Noble, Stewart A.; Walker, Richard T.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 11 p. 1329 - 1334
