2,2-二甲基-3-苯丙酸合成路线 （共 33 条）
反应条件
1: 2-methyl propanoic acid With sodium hydride; diisopropylamine in tetrahydrofuran
T=20°C; 0.25 h; Inert atmosphereReflux;
2: With n-butyllithium in tetrahydrofuran; hexane
T=0 - 35°C; 0.833333 h; Inert atmosphere;
3: benzyl bromide in tetrahydrofuran; hexane
T=0 - 35°C; 1.5 h; Inert atmosphere;
参考文献
Beaulieu, Louis-Philippe B.; Roman, Daniela Sustac; Vallee, Frederic; Charette, Andre B.
Chemical Communications, 2012 , vol. 48, # 66 p. 8249 - 8251
反应条件
sodium hydroxide
T=80°C; 5 h; Heating; Yield given;
参考文献
Muir, David J.; Stothers
Canadian Journal of Chemistry, 1993 , vol. 71, # 8 p. 1099 - 1105
反应条件
1: With indium tribromide in dichloromethane
T=20°C; 2 h;
2: With water; sodium hydrogencarbonate in dichloromethane
Saturated solution;
参考文献
Nishimoto, Yoshihiro; Saito, Takahiro; Yasuda, Makoto; Baba, Akio
Tetrahedron, 2009 , vol. 65, # 28 p. 5462 - 5471
反应条件
copper(l) chloride in tetrahydrofuran
T=0°C; 15 h;
参考文献
Kawashima, Masatoshi; Sato, Toshio; Fujisawa, Tamotsu
Tetrahedron, 1989 , vol. 45, # 2 p. 403 - 412
反应条件
copper(l) iodide in tetrahydrofuran
T=0°C; 0.25 h;
参考文献
Sato, Toshio; Kawara, Tatsuo; Kawashima, Masatoshi; Fujisawa, Tamotsu
Chemistry Letters, 1980 , p. 571 - 574
反应条件
hydrogenchloride
1.) THF, 70 deg C, 5h, 2.) 25 deg C; Yield given. Multistep reaction;
参考文献
Arnold, Richard T.; Kulenovic, Srdanka T.
Journal of Organic Chemistry, 1980 , vol. 45, # 5 p. 891 - 894
反应条件
1: (i) KOtBu, DMSO, benzene, (ii) /BRN= 471308/
2: H2O2
3: aq. NaOH / methanol
View Scheme
参考文献
Cocker,W.; Grayson,D.H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1975 , p. 1347 - 1352
反应条件
1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 °C
1.2: 16 h / -78 - 20 °C
1.3: 0 °C
2.1: water; sodium hydroxide / methanol / 60 °C
2.2: pH 2
View Scheme
参考文献
Hasegawa, Nao; Charra, Valentine; Inoue, Satoshi; Fukumoto, Yoshiya; Chatani, Naoto
Journal of the American Chemical Society, 2011 , vol. 133, # 21 p. 8070 - 8073
反应条件
hydrogenchloride; sodium nitrite
T=0°C;
参考文献
Haller; Bauer
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1909 , vol. 149, p. 8
Annales de Chimie (Cachan, France), 1913 , vol. <8> 28, p. 399
反应条件
sulfuric acid; sodium nitrite
T=0°C;
参考文献
Haller; Bauer
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1909 , vol. 149, p. 8
Annales de Chimie (Cachan, France), 1913 , vol. <8> 28, p. 399
