(4R)-4-乙基-4-[(E)-2-(2-呋喃基)乙烯基]-1,3-恶唑烷-2-酮合成路线 （共 4 条）
反应条件
1: With sodium hydroxide in tetrahydrofuran; methanol; water
T=20°C; 3 h; Alkaline aqueous solution;
2: With potassium tert-butylate in tetrahydrofuran
T=20°C; 3 h;
参考文献
Sankyo Company, Limited
Patent: EP1471054 A1, 2004 ;
Location in patent: Page 300 ;
反应条件
1.1: TOYOBO / diisopropyl ether / 4 h / 20 °C
2.1: pyridinium dichromate; molecular sieves 4 Angstroem / CH2Cl2 / 2 h / 20 °C
3.1: potassium tert-butoxide / tetrahydrofuran / 0.25 h / cooling
3.2: tetrahydrofuran / 0.58 h / cooling
4.1: NaOH / methanol; tetrahydrofuran; H2O / 3 h / 20 °C
4.2: potassium tert-butoxide / tetrahydrofuran / 3 h / 20 °C
View Scheme
参考文献
Nakamura, Tsuyoshi; Tsuji, Takashi; Iio, Yukiko; Miyazaki, Shojiro; Takemoto, Toshiyasu; Nishi, Takahide
Tetrahedron Asymmetry, 2006 , vol. 17, # 19 p. 2781 - 2792
反应条件
1.1: potassium tert-butoxide / tetrahydrofuran / 0.25 h / cooling
1.2: tetrahydrofuran / 0.58 h / cooling
2.1: NaOH / methanol; tetrahydrofuran; H2O / 3 h / 20 °C
2.2: potassium tert-butoxide / tetrahydrofuran / 3 h / 20 °C
View Scheme
参考文献
Nakamura, Tsuyoshi; Tsuji, Takashi; Iio, Yukiko; Miyazaki, Shojiro; Takemoto, Toshiyasu; Nishi, Takahide
Tetrahedron Asymmetry, 2006 , vol. 17, # 19 p. 2781 - 2792
反应条件
1.1: pyridinium dichromate; molecular sieves 4 Angstroem / CH2Cl2 / 2 h / 20 °C
2.1: potassium tert-butoxide / tetrahydrofuran / 0.25 h / cooling
2.2: tetrahydrofuran / 0.58 h / cooling
3.1: NaOH / methanol; tetrahydrofuran; H2O / 3 h / 20 °C
3.2: potassium tert-butoxide / tetrahydrofuran / 3 h / 20 °C
View Scheme
参考文献
Nakamura, Tsuyoshi; Tsuji, Takashi; Iio, Yukiko; Miyazaki, Shojiro; Takemoto, Toshiyasu; Nishi, Takahide
Tetrahedron Asymmetry, 2006 , vol. 17, # 19 p. 2781 - 2792
