3-氯-1,2-苯并异噻唑-1,1-二氧化物合成路线 （共 29 条）
反应条件
triethylamine in toluene
参考文献
Bachman; Baker; Roman
Journal of Pharmaceutical Sciences, 1978 , vol. 67, # 9 p. 1323 - 1325
反应条件
1: 94 percent / (C2H5)3N / N,N-dimethyl-acetamide / 0.5 h / Ambient temperature
2: 1.) (C2H5)3N, 3.) (C2H5)3N / 1.) N-methylpyrrolidone, room temp., 3 h, 2.) 10 min., 3.) 12 h
View Scheme
参考文献
Ueda, Mitsuru; Kawaharasaki, Naomi; Imai, Yoshio
Synthesis, 1982 , # 11 p. 933 - 935
反应条件
triethylamine in N,N-dimethyl acetamide
0.5 h; Ambient temperature;
参考文献
Ueda, Mitsuru; Kawaharasaki, Naomi; Imai, Yoshio
Synthesis, 1982 , # 11 p. 933 - 935
反应条件
triethylamine in N,N-dimethyl acetamide
0.5 h; Ambient temperature;
参考文献
Ueda, Mitsuru; Kawaharasaki, Naomi; Imai, Yoshio
Synthesis, 1982 , # 11 p. 933 - 935
反应条件
1: 60 percent
2: aq. H2O2, K2CO3, p-tolyl methyl sulfide / methanol
3: 40 percent / tetrahydrofuran / 5 h / -78 °C
View Scheme
参考文献
Page, Philip C. Bulman; Bethell, Donald; Stocks, Paul A.; Heer, Jag P.; Graham, Andrew E.; et al.
Synlett, 1997 , # 12 p. 1355 - 1358
反应条件
sodium tetrahydroborate
1.) THF, 24 h, room temperature, 2.) water; hydrolysis with 4 N HCl until pH 4; Yield given;
参考文献
Teeninga, Herman; Engberts, Jan B. F. N.
Journal of Organic Chemistry, 1983 , vol. 48, # 4 p. 537 - 542
反应条件
triethylamine in toluene
0.75 h; Heating;
参考文献
Brigas, Amadeu F.; Goncalves, Pedro M.; Johnstone, Robert A. W.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 17 p. 2603 - 2605
反应条件
1: 60 percent
2: aq. H2O2, K2CO3, p-tolyl methyl sulfide / methanol
3: 53 percent / tetrahydrofuran / 5 h / -78 °C
View Scheme
参考文献
Davis; Towson; Vashi; ThimmaReddy; McCauley Jr.; Harakal; Gosciniak
Journal of Organic Chemistry, 1990 , vol. 55, # 4 p. 1254 - 1261
反应条件
hydrogenchloride; triethylamine in ethanol; water; toluene
参考文献
E. R. Squibb and Sons, Inc.
Patent: US4108860 A1, 1978 ;
