2-羟基-6-甲基苯甲酸合成路线 （共 40 条）
反应条件
1: With sulfuric acid; sodium nitrite in water T=0°C; 0.5 h; 2: in water 0.5 h; Reflux;
参考文献
Baur, Benjamin; Storch, Kirsten; Martz, Kathrin E.; Goettert, Marcia I.; Richters, Andre; Rauh, Daniel; Laufer, Stefan A.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8561 - 8578
反应条件
sodium hydroxide in ethanol Heating;
参考文献
Silverman, F. Paul; Petracek, Peter D.; Heiman, Daniel F.; Fledderman, Christina M.; Warrior, Prem
Journal of Agricultural and Food Chemistry, 2005 , vol. 53, # 25 p. 9775 - 9780
反应条件
copper; β-cyclodextrin in potassium hydroxide T=80°C; 15 h;
参考文献
Journal of the American Chemical Society, , vol. 106, # 1 p. 174 - 178
反应条件
1: With boron tribromide in dichloromethane T=20°C; 14 - 20 h; 2: With hydrogenchloride in dichloromethane; water Product distribution / selectivity;
参考文献
RESVERLOGIX CORP.; JOHANSSON, Jan, O.; HANSEN, Henrik, C.; CHIACCHIA, Fabrizio, S.; WONG, Norman, C.W.
Patent: WO2007/16525 A2, 2007 ;
Location in patent: Page/Page column 108-112 ;
WO 2007/016525 A2
反应条件
potassium hydroxide in tetrahydrofuran; water Heating;
参考文献
Shen, Ruichao; Lin, Cheng Ting; Porco Jr., John A.
Journal of the American Chemical Society, 2002 , vol. 124, # 20 p. 5650 - 5651
反应条件
1.1: tetrahydrofuran; diethyl ether / 1.5 h / -78 - 0 °C 1.2: 85 percent / MeI / tetrahydrofuran; diethyl ether / 0.17 h / 0 °C 2.1: 99 percent / KOH / tetrahydrofuran; H2O / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 125, # 26 p. 7889 - 7901
反应条件
(i) (cyclization), (ii) aq. NaOH; Multistep reaction;
参考文献
Journal of the American Chemical Society, , vol. 93, p. 3237 - 3248
反应条件
1.1: palladium on activated charcoal; hydrogen / ethyl acetate / 20 °C 2.1: sulfuric acid; sodium nitrite / water / 0.5 h / 0 °C 2.2: 0.5 h / |Reflux View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 21 p. 8561 - 8578
反应条件
n-butyllithium; diethyl ether anschliessendes Behandeln mit CO2;
参考文献
Journal of Organic Chemistry, , vol. 18, p. 1679,1682
参考文献
Waterman, Peter G.; Zhong, Shou-Ming; Jeffreya, John A. D.; Zakaria, Muhamad bin
Journal of Chemical Research, Miniprint, 1985 , # 1 p. 101 - 144
