2-羟基-6-甲基苯甲酸合成路线 （共 40 条）
反应条件
sulfuric acid 27 h; Heating;
参考文献
Hamada; Hara; Kawai; Kohno; Shioiri
Tetrahedron, 1991 , vol. 47, # 40 p. 8635 - 8652
参考文献
Eliel et al.
Journal of Organic Chemistry, 1953 , vol. 18, p. 1679,1682
参考文献
Anslow; Raistrick
Biochemical Journal, 1931 , vol. 25, p. 39,44
反应条件
1: K2S2O8; aqueous NaOH
2: K2CO3; toluene / Erwaermen des Reaktionsprodukts mit aethanol. KOH
3: aq. NaOH solution / anschliessend Erwaermen mit wss. Kaliumpermanganat-Loesung und Erhitzen unter vermindertem Druck
View Scheme
参考文献
Inouye
Pharmaceutical Bulletin, 1954 , vol. 2, p. 359,365
反应条件
1: H2SO4
2: diethyl ether
View Scheme
参考文献
Eliel et al.
Journal of Organic Chemistry, 1953 , vol. 18, p. 1679,1682
反应条件
1: H2SO4
2: bromine; CCl4 / Erhitzen des Reaktionsprodukts mit wss. HCl und Essigsaeure
View Scheme
参考文献
Eliel et al.
Journal of Organic Chemistry, 1953 , vol. 18, p. 1679,1682
反应条件
1: 89 percent / DMAP; thionyl chloride / 1,2-dimethoxy-ethane / 3 h
2: 75 percent / N-bromosuccinimide; benzoyl peroxide / CCl4 / 15 h / Heating
View Scheme
参考文献
Holloway, Georgina A.; Huegel, Helmut M.; Rizzacasa, Mark A.
Journal of Organic Chemistry, 2003 , vol. 68, # 6 p. 2200 - 2204
反应条件
1: With 4-(N,N-dimethlyamino)pyridine; thionyl chloride
2: With N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
Heating;
参考文献
Hilli, Ferdows; White, Jonathan M.; Rizzacasa, Mark A.
Tetrahedron Letters, 2002 , vol. 43, # 47 p. 8507 - 8510
反应条件
1: K2S2O8; aqueous NaOH
2: K2CO3; toluene / Erwaermen des Reaktionsprodukts mit aethanol. KOH
3: aq. NaOH solution / anschliessend Erwaermen mit wss. Kaliumpermanganat-Loesung und Erhitzen unter vermindertem Druck
4: lithium alanate; benzene; diethyl ether
View Scheme
参考文献
Inouye
Pharmaceutical Bulletin, 1954 , vol. 2, p. 359,365
反应条件
in tetrahydrofuran; diethyl ether
T=20 - 60°C; 6 h; Product distribution / selectivity;
参考文献
RESVERLOGIX CORP.; JOHANSSON, Jan, O.; HANSEN, Henrik, C.; CHIACCHIA, Fabrizio, S.; WONG, Norman, C.W.
Patent: WO2007/16525 A2, 2007 ;
Location in patent: Page/Page column 108-112 ;
WO 2007/016525 A2
