(R)-(+)-阿替洛尔合成路线 （共 13 条）
反应条件
sodium hydroxide in water T=10 - 15°C; 2 h;
参考文献
WO2006/46252 A2, ;
Page/Page column 14 ;
反应条件
ammonium hydroxide in methanol Ambient temperature;
参考文献
Bevinakatti; Banerji
Journal of Organic Chemistry, 1992 , vol. 57, # 22 p. 6003 - 6005
反应条件
1: 95 percent / NaHSO3 / Heating 2: pyridine / 48 h / Ambient temperature 3: 43 h / Ambient temperature; lipase from Pseudomonas cepacia (LAPS) 4: NaOH / H2O / 7 h / Ambient temperature 5: 70 percent / NH4OH / methanol / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 57, # 22 p. 6003 - 6005
反应条件
1: pyridine / 48 h / Ambient temperature 2: 43 h / Ambient temperature; lipase from Pseudomonas cepacia (LAPS) 3: NaOH / H2O / 7 h / Ambient temperature 4: 70 percent / NH4OH / methanol / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 57, # 22 p. 6003 - 6005
反应条件
methanol 12 h; Ambient temperature;
参考文献
Kitaori, Kazuhiro; Takehira, Yoshikazu; Furukawa, Yoshiro; Yoshimoto, Hiroshi; Otera, Junzo
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 2 p. 412 - 414
反应条件
1: 43 h / Ambient temperature; lipase from Pseudomonas cepacia (LAPS) 2: NaOH / H2O / 7 h / Ambient temperature 3: 70 percent / NH4OH / methanol / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 57, # 22 p. 6003 - 6005
反应条件
1: 87 percent / H2O / 24 h / Ambient temperature 2: 70 percent / NH4OH / methanol / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 57, # 22 p. 6003 - 6005
反应条件
1: butan-1-ol; diisopropyl ether / 48 h / Ambient temperature; lipase from Pseudomonas cepacia (LAPS) 2: 87 percent / H2O / 24 h / Ambient temperature 3: 70 percent / NH4OH / methanol / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 57, # 22 p. 6003 - 6005
反应条件
1: NaOH / H2O / 7 h / Ambient temperature 2: 70 percent / NH4OH / methanol / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 57, # 22 p. 6003 - 6005
反应条件
AmyCoat (150x46 mm, 3 μm size silica particle) in ethanol; n-heptane; diethylamine T=27°C; Resolution of racemate;
参考文献
Chirality, , vol. 22, # 1 p. 24 - 28
