7-溴-2-甲基-4-羟基喹啉合成路线 （共 5 条）
反应条件
in diphenylether
1.5 h; Reflux;
参考文献
GLAXOSMITHKLINE LLC; BROWN, Kristin, K.; CHAI, Deping; DODSON, Christopher, S.; DUFFY, Kevin, J.; SHAW, Antony, Nicholas
Patent: WO2013/96153 A1, 2013 ;
Location in patent: Page/Page column 163 ;
反应条件
1: 18 h / 105 °C
2: diphenylether / 0.5 h / |Reflux
3: water; sodium hydroxide / ethanol / 18 h / |Reflux
4: diphenylether / 1.5 h / |Reflux
View Scheme
参考文献
GLAXOSMITHKLINE LLC; BROWN, Kristin, K.; CHAI, Deping; DODSON, Christopher, S.; DUFFY, Kevin, J.; SHAW, Antony, Nicholas
Patent: WO2013/96153 A1, 2013 ;
反应条件
1: diphenylether / 0.5 h / |Reflux
2: water; sodium hydroxide / ethanol / 18 h / |Reflux
3: diphenylether / 1.5 h / |Reflux
View Scheme
参考文献
GLAXOSMITHKLINE LLC; BROWN, Kristin, K.; CHAI, Deping; DODSON, Christopher, S.; DUFFY, Kevin, J.; SHAW, Antony, Nicholas
Patent: WO2013/96153 A1, 2013 ;
反应条件
1: water; sodium hydroxide / ethanol / 18 h / |Reflux
2: diphenylether / 1.5 h / |Reflux
View Scheme
参考文献
GLAXOSMITHKLINE LLC; BROWN, Kristin, K.; CHAI, Deping; DODSON, Christopher, S.; DUFFY, Kevin, J.; SHAW, Antony, Nicholas
Patent: WO2013/96153 A1, 2013 ;
反应条件
hydrogenchloride; water
Erhitzen des Reaktionsprodukts in Paraffinoel auf 280grad;
参考文献
Munavalli et al.
Journal of the Karnatak University, 1956 , vol. 1, p. 23,26
Full Text Show Details
Hughes; Lions
Journal and Proceedings of the Royal Society of New South Wales, 1937 , vol. 71, p. 458,459
