1-氯-3-[4-(2-甲氧基乙基)苯氧基]-2-丙醇合成路线 （共 7 条）
反应条件
morpholine; 2,4,6-trichloro-1,3,5-triazine in water
T=20°C; 0.5 h;
参考文献
Das, Biswanath; Venkateswarlu, Katta; Krishnaiah, Maddeboina
Helvetica Chimica Acta, 2007 , vol. 90, # 1 p. 149 - 152
参考文献
Melgar-Fernandez, Roberto; Demare, Patricia; Hong, Enrique; Rosas, Miguel Angel; Escalante, Jaime; Munoz-Muniz, Omar; Juaristi, Eusebio; Regla, Ignacio
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 1 p. 191 - 194
反应条件
1: methanol
2: H2; AcOH / Pd/C
3: 10 percent / aq. NaOH
View Scheme
参考文献
Melgar-Fernandez, Roberto; Demare, Patricia; Hong, Enrique; Rosas, Miguel Angel; Escalante, Jaime; Munoz-Muniz, Omar; Juaristi, Eusebio; Regla, Ignacio
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 1 p. 191 - 194
反应条件
1: CuBr2 / ethyl acetate
2: methanol
3: H2; AcOH / Pd/C
4: 10 percent / aq. NaOH
View Scheme
参考文献
Melgar-Fernandez, Roberto; Demare, Patricia; Hong, Enrique; Rosas, Miguel Angel; Escalante, Jaime; Munoz-Muniz, Omar; Juaristi, Eusebio; Regla, Ignacio
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 1 p. 191 - 194
反应条件
1: 4-(2-methoxy-ethyl)-phenol With potassium hydroxide in methanol
T=40 - 45°C; 1 h;
2: epichlorohydrin T=40°C; 24 h;
3: With acetic acid; lithium chloride in tetrahydrofuran
T=20°C; 48 h;
参考文献
Regla, Ignacio; Luviano-Jardon, Axel; Demare, Patricia; Hong, Enrique; Torres-Gavilan, Alejandro; Lopez-Munguia, Agustin; Castillo, Edmundo
Tetrahedron Asymmetry, 2008 , vol. 19, # 21 p. 2439 - 2442
反应条件
1: H2; AcOH / Pd/C
2: 10 percent / aq. NaOH
View Scheme
参考文献
Melgar-Fernandez, Roberto; Demare, Patricia; Hong, Enrique; Rosas, Miguel Angel; Escalante, Jaime; Munoz-Muniz, Omar; Juaristi, Eusebio; Regla, Ignacio
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 1 p. 191 - 194
反应条件
1.1: NaOH / 12 h / 20 °C
2.1: β-cyclodextrin / H2O; acetone / 60 °C
2.2: 91 percent / thionyl chloride / H2O; acetone / 10 h / 20 °C
View Scheme
参考文献
Surendra; Srilakshmi Krishnaveni; Nageswar; Rama Rao
Synthetic Communications, 2005 , vol. 35, # 16 p. 2195 - 2201
