N-羧氧苄基-L-谷氨酸甲酯合成路线 （共 38 条）
反应条件
Bacillus licheniformis Glu-specific endopeptidase (BL-GSE); sodium chloride; calcium chloride T=25°C; Condensation; pH=8.0; Product distribution; Further Variations:Temperatures;
参考文献
Wehofsky, Nicole; Haensler, Marion; Kirbach, Sebastian W.; Wissmann, Johannes-Dieter; Bordusa, Frank
Tetrahedron Asymmetry, 2000 , vol. 11, # 11 p. 2421 - 2428
反应条件
1: (i) ClCO2Et, Et3N, (ii) /BRN= 102415/ 2: (i) Ag2O, MeOH, (ii) aq. HCl View Scheme
参考文献
Clarke,C.T.; Jones,J.H.
Tetrahedron Letters, 1977 , p. 2367 - 2368
反应条件
2: diethyl ether 3: 75 percent / <Rh(OAc)2>2 / benzene / 0.5 h / Heating View Scheme
参考文献
Ko, Kwang-Youn; Lee, Kee-In; Kim, Wan-Loo
Tetrahedron Letters, 1992 , vol. 33, # 44 p. 6651 - 6652
反应条件
1: 82 percent / Et3N / CH2Cl2 / -5 °C 2: 85 percent / diethyl ether / -5 °C 3: 97 percent / HCl / diethyl ether / -5 °C 4: 96 percent / NaBH4 / methanol 5: 66 percent / Et3N / CH2Cl2 6: 35 percent / NaH / dimethylformamide / 85 °C 7: K2CO3 / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 29, # 18 p. 2231 - 2234
反应条件
ammonium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide in tetrahydrofuran
15 h; Ambient temperature;
参考文献
Dzierzbicka, Krystyna; Kolodziejczyk, Aleksander M.
Polish Journal of Chemistry, 1991 , vol. 65, # 7-8 p. 1437 - 1439
反应条件
Staphylococcus aureus V8 proteinase; triethylamine in water; acetonitrile
T=30°C; 24 h;
参考文献
Cerovsky, Vaclav
Tetrahedron Letters, 1991 , vol. 32, # 28 p. 3421 - 3424
反应条件
sodium tetrahydroborate; oxalyl dichloride; N,N-dimethyl-formamide
1.) acetonitrile, THF, -30 deg C, 1 h, 2.) acetonitrile, THF, from - 30 deg C to RT, 3 h; Yield given. Multistep reaction;
参考文献
Sutherland; Willis
Journal of Labelled Compounds and Radiopharmaceuticals, 1996 , vol. 38, # 1 p. 95 - 102
反应条件
1: H2SO4
2: N2H4*H2O
View Scheme
参考文献
Geiger,R. et al.
Chemische Berichte, 1963 , vol. 96, p. 1080 - 1087
Full Text Show Details
Klieger,E.; Gibian,H.
Justus Liebigs Annalen der Chemie, 1962 , vol. 655, p. 195 - 210
