4-苯基-2-甲硫基嘧啶合成路线 (共 18 条)
反应条件
1: in tetrahydrofuran
T=0°C; 2 h;
2: With acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone in tetrahydrofuran
T=20°C; 0.75 h;
参考文献
Itami, Kenichiro; Yamazaki, Daisuke; Yoshida, Jun-Ichi
Journal of the American Chemical Society, 2004 , vol. 126, # 47 p. 15396 - 15397
反应条件
1: With iron-(III)-acetylacetonate in tetrahydrofuran
T=-30°C; 0.833333 h;
2: With water in tetrahydrofuran
Product distribution / selectivity;
参考文献
Furstner, Alois; Leitner, Andreas; Mendez, Maria
Patent: US2003/220498 A1, 2003 ;
Location in patent: Page/Page column 7 ;
反应条件
iron (III) acetylacetonate in tetrahydrofuran
参考文献
Fuerstner, Alois; Leitner, Andreas; Mendez, Maria; Krause, Helga
Journal of the American Chemical Society, 2002 , vol. 124, # 46 p. 13856 - 13863
反应条件
1: 2-(Methylthio)-3,4-dihydropyrimidin-4-one With triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate in 1,4-dioxane
T=20°C; 2 h; Inert atmosphereSealed tube;
2: 3,4,5-trimethoxyphenylboronic acid With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate in 1,4-dioxane; water
T=100°C; Suzuki coupling; 4 h; Inert atmosphereSealed tube; chemoselective reaction;
参考文献
Cernova, Miroslava; Pohl, Radek; Klepetarova, Blanka; Hocek, Michal
Synlett, 2012 , vol. 23, # 9 p. 1305 - 1308
反应条件
bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide
T=100°C; 8 h;
参考文献
Solberg, Jan; Undheim, Kjell
Acta Chemica Scandinavica, 1989 , vol. 43, # 1 p. 62 - 68
参考文献
American Cyanamid Company
Patent: US4209621 A1, 1980 ;
反应条件
bis-triphenylphosphine-palladium(II) chloride in 1,2-dichloro-ethane
4 h; Heating;
参考文献
Majeed, Amera J.; Antonsen, Oyvind; Benneche, Tore; Undheim, Kjell
Tetrahedron, 1989 , vol. 45, # 4 p. 993 - 1006
反应条件
sodium ethanolate in ethanol
1 h; Heating;
参考文献
Zvezdina, E. A.; Zhdanova, M. P.; Giryavenko, I. I.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , vol. 19, # 7 p. 714 - 719
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , vol. 19, # 7 p. 893 - 898
反应条件
in N,N-dimethyl-formamide
参考文献
Clough, John Martin; Godfrey, Christopher Richard Ayles; Streeting, Ian Thomas; Cheetham, Rex; de Fraine, Paul John; Bartholomew, David; Eshelby, James John
Patent: US2003/60626 A1, 2003 ;
参考文献
Sansebastiano; Mosti; Menozzi; Schenone; Muratore; Petta; Debbia; Pesce Schito; Schito
Farmaco, 1993 , vol. 48, # 3 p. 335 - 355