(11beta)-21-(乙酰氧基)-3-乙氧基-11,17-二羟基-孕甾-3,5-二烯-20-酮合成路线 （共 3 条）
反应条件
1: 1.) H2, 2.) 2 N HCl / 1.) 5percent Pd-C / 1.) ethyl acetate, ethanol, 14 h, atmospheric pressure 2: NaOH / methanol View Scheme
参考文献
Hosoda; Osanai; Fukasawa; Nambara
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 7 p. 1949 - 1952
反应条件
palladium 10 on activated carbon; hydrogen in ethanol; ethyl acetate T=20°C; 0.666667 h;
参考文献
SAGE THERAPEUTICS, INC.; SALITURO, Francesco, Gerald; ROBICHAUD, Albert, Jean
Patent: WO2013/188792 A2, 2013 ;
Location in patent: Page/Page column 106; 107; 108 ;
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal 1.) ethyl acetate, ethanol, 14 h, atmospheric pressure; Yield given. Multistep reaction;
参考文献
Hosoda; Osanai; Fukasawa; Nambara
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 7 p. 1949 - 1952
