(R)-(-)-2-氯-1-苯乙醇合成路线 （共 34 条）
反应条件
[Ir(η5-C5Me5)(C6H4-2-CH2NHCH3)(NCCH3)](PF6); potassium tert-butylate in water; toluene T=20°C; 1 h; Inert atmosphere;
参考文献
Jerphagnon, Thomas; Gayet, Arnaud J.A.; Berthiol, Florian; Ritleng, Vincent; Mrsic, Natasa; Meetsma, Auke; Pfeffer, Michel; Minnaard, Adriaan J.; Feringa, Ben L.; De Vries, Johannes G.
Chemistry - A European Journal, 2009 , vol. 15, # 46 p. 12780 - 12790
反应条件
1: (R)-(+)-2-chloro-1-phenylethyl alcohol With [Ir(η5-C5Me5)(C6H4-2-CH2NHCH3)(NCCH3)](PF6); potassium tert-butylate in toluene T=20°C; 16 h; Inert atmosphere; 2: (S)-2-chloro-1-phenylethanol in toluene T=20°C; 2 h; Inert atmosphere;
参考文献
Jerphagnon, Thomas; Gayet, Arnaud J.A.; Berthiol, Florian; Ritleng, Vincent; Mrsic, Natasa; Meetsma, Auke; Pfeffer, Michel; Minnaard, Adriaan J.; Feringa, Ben L.; De Vries, Johannes G.
Chemistry - A European Journal, 2009 , vol. 15, # 46 p. 12780 - 12790
反应条件
sodium azide in N,N-dimethyl-formamide
T=100°C; 8 h;
参考文献
Boden, P. R.; Eden, J. M.; Higginbottom, M.; Hill, D. R.; Horwell, D. C.; et al.
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 1 p. 47 - 61
反应条件
1: 2 M NaOH / methanol / 3 h / Ambient temperature
2: NaN3 / dimethylformamide / 8 h / 80 °C
3: TPP, DIAD / tetrahydrofuran / 8 h / Ambient temperature
4: NH2NH2 / ethanol / 1 h / Heating
5: H2 / Pd/C / methanol / 2 h / 760 Torr
View Scheme
参考文献
Rama Rao; Gurjar; Kaiwar
Tetrahedron Asymmetry, 1992 , vol. 3, # 7 p. 859 - 862
