1-(4-氨基-3-溴-苯基)-乙烯酮合成路线 （共 15 条）
反应条件
N-bromosuccinmide T=20°C; 0.0833333 h; regioselective reaction;
参考文献
Venkateswarlu, Katta; Suneel, Kanaparthy; Das, Biswanath; Reddy, Kuravallapalli Nagabhushana; Reddy, Thummala Sreenivasulu
Synthetic Communications, 2009 , vol. 39, # 2 p. 215 - 219
反应条件
1: With hydrogenchloride in water 5 h; Heating / reflux; 2: With sodium hydrogencarbonate in water
参考文献
SANOFI-AVENTIS
Patent: WO2009/7015 A1, 2009 ;
Location in patent: Page/Page column 69-70 ;
WO 2009/007015 A1
反应条件
1: With Trimethylphenylammonium tribromide in tetrahydrofuran T=0°C; 2: With hydrogenchloride in tetrahydrofuran 1 h; Further stages.;
参考文献
Nery, Marcelo S.; Azevedo, Mariangela S.; Cardoso, Jari N.; Slana, Glaucia B. C.; Lopes, Rosangela S. C.; Lopes, Claudio C.
Synthesis, 2007 , # 10 p. 1471 - 1474
反应条件
1: diluted acetic acid; bromine 2: hydrochloric acid View Scheme
参考文献
Journal of the American Chemical Society, , vol. 50, p. 160
反应条件
1: 58 percent / FeCl3 / dimethylformamide / Heating 2: 74 percent / CuBr2 / tetrahydrofuran / Heating 3: ethanol / 0 - 2 °C 4: NaBH4 / -10 - 25 °C View Scheme
参考文献
Asato, Goro; Baker, Pamela K.; Bass, Roy T.; Bentley, T. James; Chari, Sarangan; et al.
Agricultural and Biological Chemistry, 1984 , vol. 48, # 11 p. 2883 - 2888
反应条件
hydrogenchloride; sodium nitrite 1.) H2O, 5 deg C; 2.) 40-50 deg C, 0.5 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Tagawa; Kubo
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 8 p. 3047 - 3052
反应条件
iron(III) chloride in N,N-dimethyl-formamide Heating;
参考文献
Asato, Goro; Baker, Pamela K.; Bass, Roy T.; Bentley, T. James; Chari, Sarangan; et al.
Agricultural and Biological Chemistry, 1984 , vol. 48, # 11 p. 2883 - 2888
反应条件
ethanol; sulfuric acid
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 54, p. 813,824
反应条件
1.1: hydrogenchloride / acetonitrile; water / 0.25 h / -10 - 20 °C
1.2: 0.5 h
1.3: 0.5 h / -10 - 20 °C
2.1: caesium carbonate; tetrakis(triphenylphosphine) palladium(0) / water; 1,4-dioxane / 100 °C / |Inert atmosphere
3.1: boron trifluoride diethyl etherate / acetonitrile / 4 h / 45 °C
View Scheme
参考文献
Shang, Xiaobo; Chen, Wanzhi; Yao, Yingming
Synlett, 2013 , vol. 24, # 7 art. no. ST-2013-W0104-L, p. 851 - 854
反应条件
1: 58 percent / FeCl3 / dimethylformamide / Heating
2: 74 percent / CuBr2 / tetrahydrofuran / Heating
View Scheme
参考文献
Asato, Goro; Baker, Pamela K.; Bass, Roy T.; Bentley, T. James; Chari, Sarangan; et al.
Agricultural and Biological Chemistry, 1984 , vol. 48, # 11 p. 2883 - 2888
