3,3',4,4',5,5'-己甲氧基联苯合成路线 （共 21 条）
反应条件
1: 28 percent / bromine / acetic acid
2: 6 percent / Pd(PPh3)4; aq. Na2CO3 / 1,2-dimethoxy-ethane / Heating
View Scheme
参考文献
Gaukroger, Keira; Hadfield, John A.; Hepworth, Lucy A.; Lawrence, Nicholas J.; McGown, Alan T.
Journal of Organic Chemistry, 2001 , vol. 66, # 24 p. 8135 - 8138
反应条件
methanol; ammonia; magnesium; palladium on activated charcoal
T=20°C; 1.5 h;
参考文献
Mori, Akinori; Mizusaki, Tomoteru; Ikawa, Takashi; Maegawa, Tomohiro; Monguchi, Yasunari; Sajiki, Hironao
Chemistry - A European Journal, 2007 , vol. 13, # 5 p. 1432 - 1441
反应条件
1: 5-bromo-1,2,3-trimethoxy-benzene With n-butyllithium in tetrahydrofuran
T=-78°C; 0.5 h; Inert atmosphere;
2: With zinc(II) chloride in tetrahydrofuran
T=-78 - 20°C; 0.5 h; Inert atmosphere;
3: N-phenyl phthalimide With [2,2']bipyridinyl; bis(1,5-cyclooctadiene)nickel (0) in tetrahydrofuran; 1,4-dioxane
T=95°C; 16 h; Inert atmosphere;
参考文献
Havlik, Sarah E.; Simmons, Jessica M.; Winton, Valerie J.; Johnson, Jeffrey B.
Journal of Organic Chemistry, 2011 , vol. 76, # 9 p. 3588 - 3593
反应条件
copper(II) oxide
T=340°C;
参考文献
Baker,W. et al.
Journal of the Chemical Society, 1963 , p. 922 - 927
参考文献
Ewald
Chemische Berichte, 1878 , vol. 11, p. 1623
反应条件
1: 91 percent / NaH
2: 27 percent / pyridine / CHCl3 / 60 °C
View Scheme
参考文献
Combes; Finet; Siri
Journal of the Chemical Society. Perkin Transactions 1, 2002 , vol. 2, # 1 p. 38 - 44
反应条件
1: 93 percent / BF3*Et2O / acetic acid / 2 h / 70 °C
2: 91 percent / NaH
3: 27 percent / pyridine / CHCl3 / 60 °C
View Scheme
参考文献
Combes; Finet; Siri
Journal of the Chemical Society. Perkin Transactions 1, 2002 , vol. 2, # 1 p. 38 - 44
反应条件
copper bronze
1.) 240 deg C, 0.5 h, 2.) from 240 deg C to 280 deg C, 0.5 h; Further byproducts given;
参考文献
Bowden, Bruce F.; Read, Roger W.; Taylor, Walter C.
Australian Journal of Chemistry, 1981 , vol. 34, # 4 p. 799 - 817
参考文献
Baker,W. et al.
Journal of the Chemical Society, 1964 , p. 1067 - 1072
反应条件
1: (i) NaNO2, aq. H2SO4, (ii) aq. KI
2: Cu, PhI / 240 °C
View Scheme
参考文献
Erdtman,H. et al.
Acta Chemica Scandinavica (1947-1973), 1963 , vol. 17, p. 1151 - 1156
