3-氨基-3-(4-甲氧基苯基)丙酸合成路线 （共 19 条）
反应条件
methanol; hydroxylamine
参考文献
Justus Liebigs Annalen der Chemie, , vol. 389, p. 36,111
参考文献
Archiv der Pharmazie (Weinheim, Germany), , p. 119
反应条件
sodium hydrogencarbonate in 1,4-dioxane; water T=20°C; 24 h;
参考文献
Sulyok; Gibson; Goodman; Hoelzemann; Wiesner; Kessler
Journal of Medicinal Chemistry, 2001 , vol. 44, # 12 p. 1938 - 1950
反应条件
sodium hydroxide in 1,4-dioxane; water 1.) 0 deg C, 10 min, 2.) RT, 3 h;
参考文献
Kalvin, Douglas M.; Woodard, Ronald W.
Journal of Organic Chemistry, 1985 , vol. 50, # 13 p. 2259 - 2263
参考文献
Rodionow et al.
Zhurnal Obshchei Khimii, 1957 , vol. 27, p. 2234,2236; engl. Ausg. S. 2293, 2294
反应条件
1: 64 percent / triethylamine / H2O; acetone / a) -5 deg C, 2 h, b) RT, 3 h 2: 61 percent / aq. KOH / Ambient temperature; penicillin acylase (EC 3.5.1.11), pH 7.5 View Scheme
参考文献
Li, Dengchao; Ji, Lilian; Wang, Xinfeng; Wei, Dongzhi
Preparative Biochemistry and Biotechnology, 2013 , vol. 43, # 2 p. 207 - 216
反应条件
1: 64 percent / triethylamine / H2O; acetone / a) -5 deg C, 2 h, b) RT, 3 h 3: 6 N aq. HCl / 11 h / 50 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 6, # 7 p. 1601 - 1610
反应条件
recombinant Alcaligenes faecalis penicillin G acylase in aq. phosphate buffer T=25°C; pH=11; 1.5 h; Enzymatic reaction; enantioselective reaction;
参考文献
Preparative Biochemistry and Biotechnology, , vol. 43, # 2 p. 207 - 216
反应条件
1: thionyl chloride / 2 h / Heating 2: triethylamine / benzene / Heating View Scheme
参考文献
Lebedev; Lebedeva; Sheludyakov; Ovcharuk; Kovaleva; Ustinova
Russian Journal of General Chemistry, 2006 , vol. 76, # 7 p. 1069 - 1080
