6-碘-1,2,3,4-四氢萘合成路线 （共 3 条）
反应条件
1.1: 2,2'-azo-bisisobutyronitrile; N-bromosuccinmide / tetrachloromethane / 1 h / 80 °C / Inert atmosphere 2.1: tetreamethyl ammonium hydroxide / N,N-dimethyl-formamide / 2.5 h / 20 °C / Inert atmosphere 2.2: 16 h / 20 °C / Inert atmosphere 3.1: 50 - 180 °C / 40 Torr View Scheme
参考文献
Ricoh Company, Ltd.; GOTO, Daisuke; YAMAMOTO, Satoshi; SAGISAKA, Toshiya; KATO, Takuji; OKADA, Takashi; SHINODA, Masato; MATSUMOTO, Shinji; MOHRI, Masataka; YUTANI, Keiichiro
Patent: WO2011/30918 A1, 2011 ;
反应条件
1: With hydrogenchloride; sodium nitrite in water
T=5°C; 1 h;
2: With potassium iodide in water
T=60°C;
参考文献
Ricoh Company, Ltd.; GOTO, Daisuke; YAMAMOTO, Satoshi; SAGISAKA, Toshiya; KATO, Takuji; OKADA, Takashi; SHINODA, Masato; MATSUMOTO, Shinji; MOHRI, Masataka; YUTANI, Keiichiro
Patent: WO2011/30918 A1, 2011 ;
Location in patent: Page/Page column 101-103 ;
反应条件
iodine; silver nitrate in dichloromethane
T=0 - 20°C; 70 - 72 h; Product distribution / selectivity;
参考文献
ASTRAZENECA AB; ASTEX THERAPEUTICS LTD
Patent: WO2007/58602 A2, 2007 ;
Location in patent: Page/Page column 118; 208-209 ;
WO 2007/058602 A2
