Rapp TentaGel S RAM resin; water; tris-(o-tolyl)phosphine; trifluoroacetic acid; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0) 1.) EDC, DMF; 2.) dioxane, 70-80 deg C, 16-20 h; Yield given. Multistep reaction;

lithium aluminium deuteride in tetrahydrofuran 15 h; Ambient temperature;

1: 40 percent / Et3N / benzene / 2 h / Ambient temperature 2: 55 percent / LiAlD4 / diethyl ether / 1 h / Ambient temperature View Scheme